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Molecular dissection of the pseudokinase ZED1 expands effector recognition to the tomato immune receptor ZAR1.
- Published in:
- Plant Physiology, 2024, v. 196, n. 1, p. 651, doi. 10.1093/plphys/kiae268
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- Article
Inhibitors identify an auxiliary role for mTOR signalling in necroptosis execution downstream of MLKL activation.
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- Biochemical Journal, 2024, v. 481, n. 17, p. 1125, doi. 10.1042/BCJ20240255
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- Article
Ars Moriendi; the art of dying well - new insights into the molecular pathways of necroptotic cell death.
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- EMBO Reports, 2014, v. 15, n. 2, p. 155, doi. 10.1002/embr.201337970
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- Article
Dynamics of necroptosis in kidney ischemia-reperfusion injury.
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- Frontiers in Immunology, 2023, p. 01, doi. 10.3389/fimmu.2023.1251452
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- Article
Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling.
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- Science Signaling, 2021, v. 14, n. 668, p. 1, doi. 10.1126/scisignal.abc6178
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- Article
Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid–binding residues.
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- Science Signaling, 2020, v. 13, n. 636, p. 1, doi. 10.1126/scisignal.aaz5599
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- Article
Structure-based mechanism of preferential complex formation by apoptosis signal–regulating kinases.
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- Science Signaling, 2020, v. 13, n. 622, p. 1, doi. 10.1126/scisignal.aay6318
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- Article
Emerging concepts in pseudoenzyme classification, evolution, and signaling.
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- Science Signaling, 2019, v. 12, n. 594, p. 1, doi. 10.1126/scisignal.aat9797
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- Article
Intracranial Self-Administration of Ethanol within the Ventral Tegmental Area of Male Wistar Rats: Evidence for Involvement of Dopamine Neurons.
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- Journal of Neuroscience, 2004, v. 24, n. 5, p. 1050, doi. 10.1523/JNEUROSCI.1319-03.2004
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- Article
Targeting focal adhesion kinase in cancer cells and the tumor microenvironment.
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- Experimental & Molecular Medicine EMM, 2020, v. 52, n. 6, p. 877, doi. 10.1038/s12276-020-0447-4
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- Article
SMCHD1’s ubiquitin-like domain is required for N-terminal dimerization and chromatin localization.
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- Biochemical Journal, 2021, v. 478, n. 13, p. 2555, doi. 10.1042/BCJ20210278
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- Article
Identification of a second binding site on the TRIM25 B30.2 domain.
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- Biochemical Journal, 2018, v. 475, n. 2, p. 429, doi. 10.1042/BCJ20170427
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- Article
The epigenetic regulator Smchd1 contains a functional GHKL-type ATPase domain.
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- Biochemical Journal, 2016, v. 473, n. 12, p. 1733, doi. 10.1042/BCJ20160189
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- Article
The hinge domain of the epigenetic repressor Smchd1 adopts an unconventional homodimeric configuration.
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- Biochemical Journal, 2016, v. 473, n. 6, p. 733, doi. 10.1042/BJ20151049
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- Article
Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop.
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- Biochemical Journal, 2015, v. 471, n. 2, p. 255, doi. 10.1042/BJ20150678
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- Publication type:
- Article
Crystal structure of the mouse interleukin-3 β-receptor: insights into interleukin-3 binding and receptor activation.
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- Biochemical Journal, 2014, v. 463, n. 3, p. 393, doi. 10.1042/BJ20140863
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- Article
The molecular regulation of Janus kinase (JAK) activation.
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- Biochemical Journal, 2014, v. 462, n. 1, p. 1, doi. 10.1042/BJ20140712
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- Article
Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.
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- Biochemical Journal, 2014, v. 458, n. 2, p. 395, doi. 10.1042/BJ20131516
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- Article
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.
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- Biochemical Journal, 2014, v. 457, n. 2, p. 323, doi. 10.1042/BJ20131174
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- Article
Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL.
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- Biochemical Journal, 2014, v. 457, n. 3, p. 369, doi. 10.1042/BJ20131270
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- Article
Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues.
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- Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16823-3
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- Article
FAK in the nucleus prevents VSMC proliferation by promoting p27 and p21 expression via Skp2 degradation.
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- Cardiovascular Research, 2022, v. 118, n. 4, p. 1150, doi. 10.1093/cvr/cvab132
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- Article
Necroptosis Signalling Promotes Inflammation, Airway Remodelling and Emphysema in COPD.
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- 2021
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- Publication type:
- journal article
The PEAK family of pseudokinases, their role in cell signalling and cancer.
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- FEBS Journal, 2020, v. 287, n. 19, p. 4183, doi. 10.1111/febs.15087
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- Article
A tale of two domains - a structural perspective of the pseudokinase, MLKL.
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- FEBS Journal, 2015, v. 282, n. 22, p. 4268, doi. 10.1111/febs.13504
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- Article
Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms.
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- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-29670-1
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- Article
Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling.
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- Cell Death & Disease, 2022, v. 13, n. 6, p. 1, doi. 10.1038/s41419-022-05009-y
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- Article
The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL.
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- Cell Death & Disease, 2022, v. 13, n. 4, p. 1, doi. 10.1038/s41419-022-04740-w
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- Article
A family harboring an MLKL loss of function variant implicates impaired necroptosis in diabetes.
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- Cell Death & Disease, 2021, v. 12, n. 4, p. 1, doi. 10.1038/s41419-021-03636-5
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- Article
The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis.
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- Cell Death & Disease, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41419-021-03418-z
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- Article
The evolving world of pseudoenzymes: proteins, prejudice and zombies.
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- BMC Biology, 2016, v. 14, p. 1, doi. 10.1186/s12915-016-0322-x
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- Article
Towards quantifying uncertainty in transient climate change.
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- Climate Dynamics, 2006, v. 27, n. 2/3, p. 127, doi. 10.1007/s00382-006-0121-0
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- Article
Quantifying uncertainty in changes in extreme event frequency in response to doubled CO<sub>2</sub> using a large ensemble of GCM simulations.
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- Climate Dynamics, 2006, v. 26, n. 5, p. 489, doi. 10.1007/s00382-005-0097-1
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- Article
GLIDER: function prediction from GLIDE-based neighborhoods.
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- Bioinformatics, 2022, v. 38, n. 13, p. 3395, doi. 10.1093/bioinformatics/btac322
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- Article
GLIDE: combining local methods and diffusion state embeddings to predict missing interactions in biological networks.
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- Bioinformatics, 2020, v. 36, p. i464, doi. 10.1093/bioinformatics/btaa459
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- Article
Add necroptosis to your asthma action plan.
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- Immunology & Cell Biology, 2021, v. 99, n. 8, p. 800, doi. 10.1111/imcb.12489
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- Article
Insane in the membrane: a structural perspective of MLKL function in necroptosis.
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- Immunology & Cell Biology, 2017, v. 95, n. 2, p. 152, doi. 10.1038/icb.2016.125
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- Article
Mitogen-activated Tasmanian devil blood mononuclear cells kill devil facial tumour disease cells.
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- Immunology & Cell Biology, 2016, v. 94, n. 7, p. 673, doi. 10.1038/icb.2016.38
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- Article
FAK and Pyk2 activity promote TNF-α and IL-1β-mediated pro-inflammatory gene expression and vascular inflammation.
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- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-44098-2
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- Article
Down the rabbit hole: Is necroptosis truly an innate response to infection?
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- Cellular Microbiology, 2017, v. 19, n. 8, p. n/a, doi. 10.1111/cmi.12750
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- Article
An objective ocean temperature and salinity analysis using covariances from a global climate model.
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- Journal of Geophysical Research. Oceans, 2007, v. 112, n. C2, p. n/a, doi. 10.1029/2005JC003172
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- Article
Unsupervised Diffusion and Volume Maximization-Based Clustering of Hyperspectral Images.
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- Remote Sensing, 2023, v. 15, n. 4, p. 1053, doi. 10.3390/rs15041053
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- Article
Hyperspectral Image Clustering with Spatially-Regularized Ultrametrics.
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- Remote Sensing, 2021, v. 13, n. 5, p. 955, doi. 10.3390/rs13050955
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- Article
Serotonin mechanisms in alcohol drinking behavior.
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- Drug Development Research, 1993, v. 30, n. 3, p. 170, doi. 10.1002/ddr.430300309
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- Article
A theoretical guarantee for data completion via geometric separation.
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- PAMM: Proceedings in Applied Mathematics & Mechanics, 2017, v. 17, n. 1, p. 833, doi. 10.1002/pamm.201710384
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- Article
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27032-x
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- Article
Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26394-6
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- Article
SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25892-x
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- Publication type:
- Article
The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation.
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- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22979-3
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- Article
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22400-z
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- Article