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- Title
Does endothelin B receptor deficiency ameliorate the induction of peritoneal fibrosis in experimental peritoneal dialysis?
- Authors
Kalk, Philipp; Rɒckert, Matthias; Godes, Michael; von Websky, Karoline; Relle, Katharina; Neumayer, Hans-Hellmut; Hocher, Berthold; Morgera, Stanislao
- Abstract
Background. Peritoneal fibrosis is a serious complication of peritoneal dialysis (PD); however, the mechanisms are poorly understood. The endothelin system exhibits potent pro-fibrotic properties and is known to be stimulated in peritoneal fibrosis. Thus, our study aimed at elucidating the impact of the endothelin B (ETB) receptor on peritoneal membrane thickening by means of an ETB-deficient rat model (ETB−/−) in experimental PD.
- Subjects
DIALYSIS (Chemistry); PERITONEAL dialysis; FIBROSIS; ENDOTHELINS; PEPTIDES
- Publication
Nephrology Dialysis Transplantation, 2010, Vol 25, Issue 5, p1474
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfp652