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- Title
Serum Chitinase3‐like Protein 1 (YKL‐40) in Wheezy Infants.
- Authors
Wagdy, El Sayed; Ahmed, Ibrahim Dina
- Abstract
Background: Chitinase-3-Like Protein 1(YKL40) is an inflammatory biomarker secreted from neutrophils, epithelial cells and smooth muscle cells of airways. It has been expressed in diseases characterized by inflammation and tissue remolding of respiratory tract e.g., asthma. Little reports were described in wheezing infants. The aim of this study is to estimate serum YKL40 in wheezy infant and study its role in pathogenesis in different types of wheezes which may help in diagnosis and management of the disease. Methods: The study was carried on 49 infants with wheezes,23 has recurrent wheezes,26 has no recurrent wheezes. Detailed medical history and examination were done. Laboratory investigations were done including Complete blood count (CBC) with differential counts, C-reactive protein (CRP), blood gases were done. Chest x-ray and C.T. scan were done when required for persistent wheezing, YKL-140 was assessed by enzyme linked immune assay kits. Results: Serum YKL 40 did not show any relation to neonatal intensive care unit (NICU) admission or recurrence of wheezing. Cases with family history of asthma showed higher level compared with those without family history. Also, critical cases showed higher values compared with stable cases. However, cases without family history of wheezing and stable cases showed no difference in serum YKL 40 compared to control. No significant difference between cases and control regarding WBCs, RBCs, platelets and CRP, while cases showed lower Hb and higher, neutrophil, serum YKL40 compared with control. Serum YKL140 showed positive correlation with neutrophil counts. Conclusion: Serum YKL140 was significantly higher in wheezing infants compared to control. Cases with family history of asthma showed higher level of this marker compared with those without family history of asthma. It showed positive correlation with blood neutrophil. These results have diagnostic and prognostic significance regarding infant wheezes.
- Subjects
CHITINASE; BIOMARKERS; NEUTROPHILS; EPITHELIAL cells; MUSCLE cells
- Publication
Zagazig University Medical Journal, 2023, Vol 29, Issue 2, p620
- ISSN
1110-1431
- Publication type
Article
- DOI
10.21608/zumj.2022.161051.2634