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- Title
Bittersweet Sugars: How Unusual Glycan Structures May Connect Epithelial-to-Mesenchymal Transition and Multidrug Resistance in Cancer.
- Authors
Fonseca, Leonardo Marques da; Diniz-Lima, Israel; da Costa Santos, Marcos André Rodrigues; Franklim, Tatiany Nunes; da Costa, Kelli Monteiro; Santos, Ariely Costa dos; Morrot, Alexandre; Decote-Ricardo, Debora; Valente, Raphael do Carmo; Freire-de-Lima, Celio Geraldo; dos Reis, Jhenifer Santos; Freire-de-Lima, Leonardo
- Abstract
Cancer cells are characterized by metabolic reprogramming, which enables their survival in of-ten inhospitable conditions. A very well-documented example that has gained attraction in re-cent years and is already considered a hallmark of transformed cells is the reprogramming of carbohydrate metabolism. Such a feature, in association with the differential expression of en-zymes involved in the biosynthesis of glycoconjugates, generically known as glycosyltransfer-ases, contributes to the expression of structurally atypical glycans when compared to those ex-pressed in healthy tissues. The latest studies have demonstrated that glycophenotypic alterations are capable of modulating multifactorial events essential for the development and/or progres-sion of the disease. Herein, we will address the importance of glycobiology in modern medi-cine, focusing on the ability of unusual/truncated O-linked glycans to modulate two complex and essential phenomena for cancer progression: the acquisition of the multidrug resistance (MDR) phenotype and the activation of molecular pathways associated with the epithelial–mesenchymal transition (EMT) process, an event deeply linked with cancer metastasis.
- Subjects
GLYCAN structure; MULTIDRUG resistance; EPITHELIAL-mesenchymal transition; CARBOHYDRATE metabolism; SUGARS
- Publication
Medicines, 2023, Vol 10, Issue 6, p36
- ISSN
2305-6320
- Publication type
Article
- DOI
10.3390/medicines10060036