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- Title
Metabolic Disorders in Patients with Chronic Hepatitis B Virus Infection: Coffee as a Panacea? (ANRS CO22 Hepather Cohort).
- Authors
Barré, Tangui; Fontaine, Hélène; Pol, Stanislas; Ramier, Clémence; Di Beo, Vincent; Protopopescu, Camelia; Marcellin, Fabienne; Bureau, Morgane; Bourlière, Marc; Dorival, Céline; Petrov-Sanchez, Ventzislava; Asselah, Tarik; Delarocque-Astagneau, Elisabeth; Larrey, Dominique; Duclos-Vallée, Jean-Charles; Carrat, Fabrice; Carrieri, Patrizia
- Abstract
People living with chronic hepatitis B virus (HBV) infection are at high risk of liver disease progression, which is positively associated with metabolic disorders, but inversely associated with dyslipidemia. Diet, including dietary antioxidants, is a lever of metabolic disorder management. In particular, elevated coffee consumption is associated with different metabolic outcomes in the general population. We aimed to test whether such associations occur in HBV-infected people. Based on cross-sectional data from the ANRS CO22 Hepather cohort, we performed logistic regression models with (i) dyslipidemia, (ii) hypertension, and (iii) diabetes as outcomes, and with demographic, clinical, and socio-behavioral (including coffee consumption) data as explanatory variables. Among 4746 HBV-infected patients, drinking ≥3 cups of coffee per day was associated with a higher risk of dyslipidemia (adjusted odds ratio [95% confidence interval] 1.49 [1.10–2.00], p = 0.009) and a lower risk of hypertension (0.64 [0.50–0.82], p = 0.001). It was not associated with diabetes. Elevated coffee consumption was associated with a higher risk of dyslipidemia and a lower risk of hypertension in HBV-infected patients, two effects expected to be associated with favorable clinical outcomes. Further studies should test whether such metabolic benefits translate into reduced mortality risk in this population.
- Subjects
HEPATITIS B; CHRONIC hepatitis B; COFFEE beans; METABOLIC disorders; VIRUS diseases; HEPATITIS B virus; COFFEE
- Publication
Antioxidants, 2022, Vol 11, Issue 2, p379
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox11020379