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- Title
EXPERIMENTAL PHARMACOLOGY.
- Authors
Kesarev O. G.; Danilenko L. M.; Pokrovskii M. V.; Timokhina A. S.; Khavanskii A. V.
- Abstract
In experiments on the isolated rat heart there were studied the effects of different doses (21.43 mg/kg/day and 85.72 mg/kg/day) 2-ethyl-6-methyl-3 hydroxypyridine succinate ("EkoPharmInvest", Russia), on the contractile function of isolated hearts subjected to prior doxorubicin model (20 mg/kg, intraperitoneal) of pathology. The dynamic of the power mechanisms of ion transport was evaluated by imposing high heart rate (480 BPM) and increase concentration of Ca2+ to 5 mmol in perfusate. The results indicate that Mexicor at the dose of 21.43 mg/kg/day does not provide a cardioprotective effect in this model of pathology. Mexicor has the cardioprotective effect at the dose of 85.72 mg/kg/day in relation to the isolated heart, that is resulted in the recovery of the contractile function of the heart and reducing the "diastole defect" (STTI).
- Subjects
EXPERIMENTAL pharmacology; DOXORUBICIN; HEART rate monitoring; CARDIOTONIC agents; CONTRACTILE proteins
- Publication
Research Results in Pharmacology, 2017, Vol 3, Issue 1, p3
- ISSN
2658-381X
- Publication type
Article
- DOI
10.18413/2500-235X-2017-3-1-3-9