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- Title
Effect of Crystalline Silica Particles on PMN Release from the Bone Marrow.
- Authors
AKIRA OGAMI; YASUO MORIMOTO; HIROSHI YAMATO; TAKAKO OYABU; IZUMI AKIYAMA; TAKAYOSHI KAJIWARA; SATOSHI OMINAMI; ISAMU TANAKA
- Abstract
Previous studies have shown that immature polymorphonuclear leukocytes (PMNs) newly released from the bone marrow on pulmonary inflammation may preferentially sequester in the lung and cause endothelial damage in the lung microvessels, which may contribute to the observed decrease in lung function. The aim of this study was to determine changes in PMN release from the bone marrow induced by crystalline silica. Japanese white rabbits were exposed to crystalline silica (Min-U silica, 50 mg) (n = 6) intratracheally. The systemic inflammatory response was measured as changes in circulating 5Œ-bromo-2-deoxyuridine (BrdU)-positive PMN (PMNBrdU) newly released from the bone marrow. Silica exposure caused a shortening transit time of PMN through the bone marrow, especially in their last division in the mitotic pool, than in the control (P < 0.02). A BAL study 48 h after instillation of crystalline silica showed that the number of PMN and PMNBrdU recovered by lavage was significantly greater than from the control (P < 0.05). We conclude that, as with other inflammatory sources such as cigarette smoking, ambient particulate matter or pneumococcal pneumonia, crystalline silica instillation into the lung induces immature PMN from bone marrow and may contribute to the observed pulmonary lesion.
- Subjects
BONE marrow; INFLAMMATION; PNEUMOCOCCAL pneumonia; PULMONARY function tests; SMOKING
- Publication
Annals of Occupational Hygiene, 2002, Vol 46, p43
- ISSN
0003-4878
- Publication type
Article
- DOI
10.1093/annhyg/46.suppl_1.43