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- Title
A randomized multicenter clinical evaluation of sequential application of 0.3% and 0.15% hyaluronic acid for treatment of dry eye.
- Authors
Jun, Jong Hwa; Bang, Seung Pil; Park, Han Sang; Yoon, Donghee; Ahn, Ja Young; Kim, Seong Jae; Kim, Hong Kyun
- Abstract
Purpose: We report the clinical efficacy of sequential applications of 0.3% and 0.15% unpreserved hyaluronic acid (HA) for the treatment of dry eye disease (DED). Study design: Randomized clinical trial. Methods: Patients over 19 years of age with DED level 2 or higher, corneal fluorescein staining (CFS) score > 1, and tear break-up time (TBUT) < 10 s were included. Seventy-six patients were randomly assigned to the 0.15% HA group, 0.3% HA group, or combination group. Each group applied two drops of 0.15% or 0.3% HA, or a single drop of both 0.3% and 0.15% HA. Patients were evaluated using the ocular surface disease index (OSDI), CFS and conjunctival fluorescein stain score, TBUT, and blurring/discomfort after application at baseline, 4 weeks, and 8 weeks. Results: The combination group had the greatest improvement in CFS score from baseline to 8 weeks, compared with the 0.15% and 0.3% HA group (p < 0.001). The combined CFS-OSDI responder rates of the combination group (CFS score = 0 and OSDI ≥ 50% improvement at 8 weeks) were significantly higher than those of the 0.15% and 0.3% groups (p = 0.037). At 4 and 8 weeks, blurring after application in both the 0.3% and combination groups was significantly higher than in the 0.15% group, despite no difference between the 0.3% and combination groups. There were no differences in CFS and conjunctival staining score, TBUT, or OSDI within the three groups at baseline, 4 weeks, and 8 weeks. Conclusions: Sequential application of 0.3% and 0.15% HA improved symptoms/signs in moderate to severe DED patients.
- Subjects
HYALURONIC acid; DRY eye syndromes; CLINICAL trials; EXPERIMENTAL design
- Publication
Japanese Journal of Ophthalmology, 2022, Vol 66, Issue 1, p58
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-021-00885-x