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- Title
Assessing floor contamination by antineoplastic agents in a Japanese medical institution specializing in cancer treatment.
- Authors
Maeda, Akimitsu; Hori, Kyoko; Sone, Yumiko; Hashimoto, Naoya; Uchida, Kosaku
- Abstract
Introduction: This study investigated the extent of contamination with antineoplastic agents on floor surfaces of the ward and the outpatient chemotherapy center of a Japanese cancer center to evaluate healthcare workers' risk of occupational exposure to antineoplastic agents outside of the designated drug preparation areas. Methods: In this study conducted at Aichi Cancer Center, the amount of fluorouracil detected on various floor surfaces was measured using liquid chromatography—tandem quadrupole mass spectrometry. Areas around the toilets were cleaned with a surfactant two or three times a day, whereas other floor surfaces were cleaned only with dry and wet mops. Results: Fluorouracil was detected on all surveyed floor surfaces, with particularly high amounts detected around the toilet areas in the ward. Additionally, areas with more human traffic tended to have higher fluorouracil contamination. Conclusions: This survey suggested that antineoplastic agent contamination occurring through patient excretions might spread throughout the hospital with human traffic. Therefore, controlling the spread of antineoplastic agent contamination in hospitals should include the review of measures to mitigate contamination around toilets and to implement effective cleaning methods for floor surfaces.
- Subjects
JAPAN; CANCER treatment; RISK assessment; CLEANING compounds; OUTPATIENT services in hospitals; HUMAN services programs; ANTINEOPLASTIC agents; HOSPITALS; BOWEL &; bladder training; SURVEYS; OCCUPATIONAL exposure; DOSAGE forms of drugs; LIQUID chromatography; MASS spectrometry; SURFACE active agents; MEDICAL equipment contamination; FLUOROURACIL; SPECIALTY hospitals; PREVENTION
- Publication
Journal of Oncology Pharmacy Practice, 2024, Vol 30, Issue 5, p880
- ISSN
1078-1552
- Publication type
Article
- DOI
10.1177/10781552231190015