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- Title
A Nucleotide Substitution Responsible for the Tawny Coat Color Mutation Carried by the MSKR Inbred Strain of Mice.
- Authors
Wada, A.; Kunieda, T.; Nishimura, M.; Kakizoe-Ishida, Y.; Watanabe, N.; Ohkawa, K.; Tsudzuki, M.
- Abstract
"Tawny" is an autosomal recessive coat color mutation found in a wild population of Mus musculus molossinus. The inbred strain MSKR carries the mutation. The causative gene Mclrtaw of the tawny phenotype is the second recessive allele at the melanocortin I receptor locus and is dominant to the first recessive allele, "recessive yellow" (Mclre). The Mclrtaw gene has six nucleotide substitutions, and its forecasted transcript has three amino acid substitutions (i.e., V I01A, V216A, W252C). Though the nucleotide substitutions leading to V I01A and V216A exist in various mouse strains, the nucleotide substitution leading to W252C exists in only tawny-colored mice. Thus this substitution is considered to be responsible for the expression of the tawny coat color. The frequency of the allele having this nucleotide substitution was 9.21% in the wild M. m. molossinus population inhabiting Sakai City, Osaka Prefecture, Japan, where the ancestral mice of the MSKR strain were captured.
- Subjects
ANIMAL coloration; GENETIC mutation; PHENOTYPES; NUCLEOTIDES; ANIMALS
- Publication
Journal of Heredity, 2005, Vol 96, Issue 2, p145
- ISSN
0022-1503
- Publication type
Article
- DOI
10.1093/jhered/esi022