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- Title
紫草婴儿软膏对湿疹的治疗作用及机制.
- Authors
张小超; 陈蓬; 孔琼荣; 王莲; 万玉华; 陈鹏; 沈志强
- Abstract
Objective To study the therapeutic effects of Lithospermum Ointment/ZiCao baby ointment on Eczema, and to provide experimental basis for its clinical application. Methods The model of skin allergic eczema induced byovalbumin (OVA) in guinea pigs and the infantile eczema like model in mice induced by 2, 4-dinitrochlorobenzene(DNCB) were duplicated to evaluate the therapeutic effects of ZiCao baby ointment on experimental eczema, respectively. TUNEL method was used to investigate the effects of ZiCao baby ointment on the apoptosis of keratinocytes and lymphocyte. Results ZiCao baby ointment at 0.5, 1 and 2 g/kg could reduce the degrees of erythema, edema, scratch and total score of eczema model animals; Pathological examination showed that ZiCao baby ointment of 1, 2 g/kg ccould improve the degree of skin lesions in the guinea pigs; ZiCao baby ointment at 1, 2 g/kg could reduce the auricular swelling of the mice, and reduce the score of skin lesions, improve the degree of skin lesions in the mice. ZiCao baby ointmen increased the numbers of positive cells in the TUNEL test. Conclusion The results showed that ZiCao baby ointment had obvious therapeutic effects on experimental eczema in the animal models and the possible mechanisms were closely related to the promotion of the apoptosis of keratinocytes (KC).
- Publication
Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, 2019, Vol 40, Issue 11, p6
- ISSN
2095-610X
- Publication type
Article