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- Title
Detecting of Mitochondrial tRN<sub>ALeu(UUR)</sub> Mutations at Position A3243G in Patients with Type 2 Diabetes Mellitus in Yunnan.
- Authors
SHI Rou; LEI You-ming; SONG Dian - ping; PU Ling; HAN Rui
- Abstract
Objective To investigate the prevalence of the mitochondrial tRNALeu(UUR) mutations at position 3243A/G in patients with type 2 diabetes mellitus in Yunnan Province. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis and DNA sequencing were used to screen the point mutations of tRNALeu(UUR) 3243 A/G in 235 patients with type 2 diabetes and 128 healthy controls with normal glucose tolerance. Results There was no one carrier of the mitochondrial tRNALeu(UUR) mutation at position 3243A/G in T2DM group and control group. Conclusions The mitochondrial tRNALeu(UUR) gene at position 3243A/G mutation was uncommon and it may be not a major genetic predisposing factor of type 2 diabetic mellitus in patients of Yunnan Province.
- Publication
Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, 2014, Vol 35, Issue 3, p44
- ISSN
2095-610X
- Publication type
Article