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- Title
The Spectrum of Neurological Manifestations Associated with Gaucher Disease.
- Authors
Lal, Tamanna Roshan; Sidransky, Ellen
- Abstract
Gaucher disease, the most common lysosomal storage disorder, is due to a deficiency in the enzyme glucocerebrosidase. This leads to the accumulation of its normal substrate, glucocerebroside, in tissue macrophages, affecting the hematological, visceral, bone and neurologic systems. Gaucher disease is classified into three broad phenotypes based upon the presence or absence of neurological involvement: type 1 (non-neuronopathic), type 2 (acute neuronopathic), and type 3 (subacute neuronopathic). Phenotypically, there is a wide spectrum of visceral and neurological manifestations. Enzyme replacement is effective in managing the visceral disease; however, treating the neurological manifestations has proved to be more challenging. This review discusses the various neurological manifestations encountered in Gaucher disease, and provides a brief overview regarding the treatment and ongoing research challenges.
- Subjects
GAUCHER'S disease treatment; THERAPEUTIC use of enzymes; LYSOSOMAL storage diseases; MACROPHAGES; NEUROLOGY
- Publication
Diseases, 2017, Vol 5, Issue 1, p10
- ISSN
2079-9721
- Publication type
Article
- DOI
10.3390/diseases5010010