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- Title
Redox and pH Responsive Poly (Amidoamine) Dendrimer-Heparin Conjugates via Disulfide Linkages for Letrozole Delivery.
- Authors
Nguyen, Thanh Luan; Nguyen, Thi Hiep; Nguyen, Cuu Khoa; Nguyen, Dai Hai
- Abstract
Heparin (Hep) conjugated to poly (amidoamine) dendrimer G3.5 (P) via redox-sensitive disulfide bond (P-SS-Hep) was studied. The redox and pH dual-responsive nanocarriers were prepared by a simple method that minimized many complex steps as previous studies. The functional characterization of G3.5 coated Hep was investigated by the proton nuclear magnetic resonance spectroscopy. The size and formation were characterized by the dynamic light scattering, zeta potential, and transmission electron microscopy. P-SS-Hep was spherical in shape with average diameter about 11 nm loaded with more than 20% letrozole. This drug carrier could not only eliminate toxicity to cells and improve the drugs solubility but also increase biocompatibility of the system under reductive environment of glutathione. In particular, P-SS-Hep could enhance the effectiveness of cancer therapy after removing Hep from the surface. These results demonstrated that the P-SS-Hep conjugates could be a promising candidate as redox and pH responsive nanocarriers for cancer chemotherapy.
- Subjects
AMINES; CANCER chemotherapy; DRUG delivery systems; DRUG stability; ELECTRON microscopy; GLUTATHIONE; HEPARIN; HIGH performance liquid chromatography; HYDROGEN-ion concentration; MATERIALS testing; MOLECULAR structure; NANOSTRUCTURES; NUCLEAR magnetic resonance spectroscopy; OXIDATION-reduction reaction; PARTICLES; POLYMERS; RESEARCH funding; SOLUBILITY; SULFUR compounds; TUMORS; AROMATASE inhibitors; DESCRIPTIVE statistics; IN vitro studies
- Publication
BioMed Research International, 2017, Vol 2017, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2017/8589212