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- Title
Lamotrigine Reduces Inflammatory Response and Ameliorates Executive Function Deterioration in an Alzheimer’s-Like Mouse Model.
- Authors
Wang, Kexin; Fernandez-Escobar, Alejandro; Han, Shuhong; Zhu, Ping; Wang, Jun-Hui; Sun, Yu
- Abstract
Alzheimer’s disease (AD) has been described in the literature, to be associated with impairment of executive function which develops early in the course of disease, and an effective treatment for this clinical feature remains elusive. Preclinical studies have implied that lamotrigine, an antiepileptic agent, could be a potential treatment for executive dysfunction in AD patients. Although there have been promising results in previous studies with lamotrigine, executive function has never been measured using animal models. The aim of the present study was to evaluate the effects of lamotrigine on executive function and determine whether lamotrigine can attenuate inflammatory response in an AD mouse model. Nontransgenic and transgenic mice were treated with lamotrigine (0 or 30 mg/kg/day) in a standard laboratory chow diet starting at 3 months of age. After 6 months of continuous lamotrigine administration, there was a marked improvement in executive function and a significant attenuation in the expression of proinflammatory cytokines. These results suggest that lamotrigine could ameliorate executive dysfunction and brain inflammatory response in the mouse model of AD and early lamotrigine intervention may be a promising therapeutic strategy for AD.
- Subjects
ALZHEIMER'S disease; ANIMAL experimentation; BIOLOGICAL models; CELL culture; CYTOKINES; ENZYME-linked immunosorbent assay; FLUORESCENT antibody technique; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INFLAMMATORY mediators; INTERLEUKINS; MICE; PROBABILITY theory; RESEARCH funding; STAINS &; staining (Microscopy); STATISTICS; T-test (Statistics); WESTERN immunoblotting; LAMOTRIGINE; DATA analysis; TREATMENT effectiveness; EXECUTIVE function; DATA analysis software; DESCRIPTIVE statistics; ONE-way analysis of variance; PHARMACODYNAMICS
- Publication
BioMed Research International, 2016, Vol 2016, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2016/7810196