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- Title
A successful treatment-free remission is achievable also by chronic myeloid leukemia patients lacking optimal requirements.
- Authors
Bonifacio, Massimiliano; Scaffidi, Luigi; Miggiano, Maria Cristina; Facchinelli, Davide; Tosoni, Luca; Pezone, Sara; Griguolo, Davide; Ciotti, Giulia; Danini, Marco; Bernardelli, Andrea; Bresciani, Rita; Cavraro, Monica; Crosera, Lara; De March, Elena; Dell'Eva, Michele; Dorotea, Laura; Frison, Luca; Furlani, Lara; Gianesello, Ilaria; Lovato, Ester
- Abstract
This document, published in the Blood Cancer Journal, explores the possibility of sustained treatment-free remission (TFR) in chronic myeloid leukemia (CML) patients who do not meet optimal requirements. The study examines the outcomes of CML patients who discontinued tyrosine kinase inhibitors (TKI) outside of clinical trials. The researchers identify risk factors for discontinuation and find that the rate of sustained TFR at 12 months depends on the number of risk factors. The study also highlights the importance of deep molecular response (DMR) duration in achieving TFR success. Overall, the findings suggest that TFR is possible in CML patients even without optimal requirements. The document provides insights into managing CML and factors that influence TFR success. The study analyzes TFR outcomes based on the presence and number of non-optimal requirements, or "risk factors," for TFR. The duration of stable deep molecular response (DMR) is identified as the most significant prognostic factor for TFR success. The study reveals that even patients with non-optimal requirements still have a 50% chance of achieving TFR. The authors conclude that all CML patients can potentially achieve successful TFR if they have an optimal duration of DMR before stopping treatment and receive close molecular monitoring.
- Subjects
CHRONIC myeloid leukemia; CHRONIC leukemia
- Publication
Blood Cancer Journal, 2024, Vol 14, Issue 1, p1
- ISSN
2044-5385
- Publication type
Article
- DOI
10.1038/s41408-024-01025-7