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- Title
Light-induced GTPase activity and GTP[γS] binding in squid retinal photoreceptors.
- Authors
Brown, Joel E.; Combs, Anthony; Ackermann, Karen; Malbon, Craig C.
- Abstract
Illumination greatly increases the GTPase activity in homogenates of squid (Loligo) whole retinas or rhabdomeric membranes. Adenylylimidodiphosphate inhibits the light-insensitive (but not the light-sensitive) GTPase activity in these homogenates. Illumination also greatly increases the binding of GTP[γS] to the rhabdomeric membranes. This binding at saturating illuminations indicates that there are approximately 10–100 times more rhodopsin molecules than G-protein molecules in squid photoreceptors. Each light-activated rhodopsin molecule activates about 10 G-protein molecules which might provide amplification for the first stage of the phototransduction cascade.
- Publication
Visual Neuroscience, 1991, Vol 7, Issue 6, p589
- ISSN
0952-5238
- Publication type
Article
- DOI
10.1017/S0952523800010373