We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Preparation, Characterization and Antibacterial Activity of some New Oxazolidin-5-one Derivatives Derived from Imine Compounds.
- Authors
Muslim, Rasim Farraj; Majeed, Ismaeel Yaseen; Saleh, Suheb Eaid; Saleh, Marwan Mahmood; Owaid, Mustafa Nadhim; Abbas, Jalal Abdulkareem
- Abstract
In this research, 5- membered heterocyclic compounds as oxazolidine-5-one J1-J5 derivatives were prepared using primary aromatic amine, aromatic carbonyl compounds and chloroacetic acid. By combining primary aromatic amines and aromatic carbonyl compounds, Schiff's bases were synthesized. Schiff bases are used with the chloroacetic acid compound to prepare oxazolidine-5-one J1-J5 derivatives. The compounds J1-J5 were described using NMR spectroscopy and FT-IR. .The biological efficacy was evaluated according to maximum inhibitory concentrations (MICs) toward Staphyloccoccus aureus and Esherichia coli. The best MIC was 210 µg ml-1 for J4 against the two pathogenic bacteria, while J1, J4, and J1 did not show any inhibitory effect against all bacteria. Finally, the best chemical created, 3'-(pyrimidin-2-yl) spiro[indoline-3,2'-oxazolidine]-2,5'-dione (J4), inhibited the development of both gram-negative and positive bacteria.
- Subjects
SCHIFF bases; ANTIBACTERIAL agents; HETEROCYCLIC compounds; CHLOROACETIC acids; AROMATIC compounds
- Publication
Journal of Chemical Health Risks, 2022, Vol 12, Issue 4, p725
- ISSN
2251-6719
- Publication type
Article
- DOI
10.22034/jchr.2022.688557