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- Title
Atypical p-ANCA is not a poor prognostic marker in Postinfectious Glomerulonephritis.
- Authors
Waters, Aoife; Langlois, Valerie; Thorner, Paul; Geary, Denis
- Abstract
Postinfectious glomerulonephritis (PIGN) most commonly follows streptococcal infection. Antineutrophil cytoplasmic antibodies (ANCA) are characteristically negative in PIGN. We report on five cases who had positive atypical pANCA at presentation. The outcome was typical of other cases of PIGN with complete resolution of the glomerulonephritis in all five patients. Atypical pANCA occurs in a number of inflammatory conditions and antigenic targets may include proteins other than myeloperoxidase or proteinase 3. The presence of atypical p-ANCA does not indicate a poor prognosis.
- Subjects
GLOMERULONEPHRITIS; STREPTOCOCCAL diseases; IMMUNE complex diseases; IMMUNOGLOBULINS; ANTIGENS; PROTEINASES; PEDIATRIC nephrology
- Publication
Pediatric Nephrology, 2007, Vol 22, Issue 9, p1383
- ISSN
0931-041X
- Publication type
Report
- DOI
10.1007/s00467-007-0495-1