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- Title
Whole-grain intake in mid-life and healthy ageing in the Danish Diet, Cancer and Health cohort.
- Authors
Eriksen, Anne Kirstine; Grand, Mia Klinten; Kyrø, Cecilie; Wohlfahrt, Jan; Overvad, Kim; Tjønneland, Anne; Olsen, Anja
- Abstract
Purpose: Growing elderly populations worldwide have sparked interest in factors promoting healthy aging. Diet and other lifestyle patterns are key factors for healthy ageing; however, evidence is sparse for specific dietary guidelines that are easily implemented in everyday life. Whole grains constitute specific dietary components with unexplored potential in healthy ageing. Methods: We applied an illness-death multistate model to assess the association between whole-grain intake and life expectancy, both with and without disease, over a 20-year period. Healthy ageing was defined as absence of cancer, ischemic heart disease, stroke, type 2 diabetes, asthma, chronic obstructive pulmonary disease, and dementia during follow-up. Results: Based on information from 22,606 men and 25,468 women in the Danish Diet, Cancer and Health cohort, followed for an average of 13.8 and 17.5 years, respectively, a doubling in whole-grain intake was associated with 0.43 (95% CI: 0.33–0.52) and 0.15 (0.06–0.24) additional years without disease for men and women, respectively. Comparing the highest and lowest quartiles of whole-grain intake, with a special emphasis on men, we found that those with the highest intake lived, on average, one year longer without disease compared to those with the lowest intake. Additionally, although a high intake of whole grains yielded longer life expectancy, the duration of living with disease was shorter. Conclusion: Intake of whole grains in mid-life was associated with healthy ageing looking 20 years ahead.
- Subjects
DENMARK; DEMENTIA prevention; TUMOR prevention; LIFESTYLES; FOOD consumption; RESEARCH funding; LIFE expectancy; GRAIN; CARDIOVASCULAR diseases risk factors; DESCRIPTIVE statistics; LONGITUDINAL method; AGING; TYPE 2 diabetes; OBSTRUCTIVE lung diseases; CONFIDENCE intervals; DIET; ACTIVE aging
- Publication
European Journal of Nutrition, 2024, Vol 63, Issue 5, p1581
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-024-03357-3