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- Title
Extrato aquoso de Allium sativum potencializa a ação dos antibióticos vancomicina, gentamicina e tetraciclina frente Staphylococcus aureus.
- Authors
Domingues Almeida, Graziela; Pena Godoi, Ednalva; Cardoso Santos, Eliziaria; Paes de Lima, Leonardo Ramos; de Oliveira, Maria Emilia
- Abstract
The present study aimed to analyze the influence of (Allium sativum) aqueous extract activity in the minimum inhibitory concentration of antibiotics against S. aureus, in vitro, and its synergistic effect with vancomycin, gentamicin, and tetracycline. The synergy tests were performed by Kirby-Bauer method. The association of the extract with each antibiotic in isolation was effective in inhibiting the growth of S. aureus strain. The greatest evidence of synergism was observed in the combination of extract with vancomycin. The synergy tests results were submitted to Wilcoxon's t-test (p <0.01). Regarding the results obtained in this study, the association of antibiotic therapy with garlic extract can represent a promising therapeutic tool for the treatment of bacterial diseases with possibility of reduction in the toxicity degree and bacterial resistance to antibiotics.
- Subjects
THERAPEUTIC use of plant extracts; GARLIC; ANTIBIOTICS; VANCOMYCIN; GENTAMICIN; TETRACYCLINE; STAPHYLOCOCCUS aureus; WILCOXON signed-rank test; THERAPEUTICS
- Publication
Revista de Ciências Farmacêuticas Básica e Aplicada, 2013, Vol 34, Issue 4, p487
- ISSN
1808-4532
- Publication type
Article