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- Title
Proliferative Tumor Doubling Times of Prostatic Carcinoma.
- Authors
Werahera, Priya N.; Glode, L. Michael; La Rosa, Francisco G.; Lucia, M. Scott; Crawford, E. David; Easterday, Kenneth; Sullivan, Holly T.; Sidhu, Rameshwar S.; Genova, Elizabeth; Hedlund, Tammy
- Abstract
Prostate cancer (PCa) has a variable biology ranging from latent cancer to extremely aggressive tumors. Proliferative activities of cancers may indicate their biological potential. A flow cytometric assay to calculate maximum proliferative doubling times (Tmax) of PCa in radical prostatectomy specimens after preoperative in vivo bromodeoxyuridine (BrdU) infusion is presented. Only 4/17 specimens had tumors large enough for flow cytometric analysis. The Tmax of tumors was similar and ranged from 0.6 to 3.6 months. Tumors had calculated doubling times 2- to 25-fold faster than their matched normal tissue. Variations in labeling index and Tmax were observed within a tumor as well as between different Gleason grades. The observed PSA doubling times (PSA-DT) ranged from 18.4 to 32.0 months, considerably slower than the corresponding Tmax of tumors involved. While lack of data for apoptotic rates is a limitation, apparent biological differences between latent versus aggressive PCa may be attributable to variations in apoptotic rates of these tumors rather than their cell proliferative rates.
- Subjects
PROSTATE cancer; CANCER cell proliferation; FLOW cytometry; PROSTATECTOMY; BROMODEOXYURIDINE; TISSUES
- Publication
Prostate Cancer (20903111), 2011, p1
- ISSN
2090-3111
- Publication type
Article
- DOI
10.1155/2011/301850