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- Title
Antifungal and antiaflatoxigenic activities of thymol and carvacrol against Aspergillus flavus.
- Authors
Nakasugi, Lydiana Pollis; Silva Bomfim, Natália; Romoli, Jessica Cristina Zoratto; Botião Nerilo, Samuel; Veronezi Silva, Milena; Rocha Oliveira, Gustavo Henrique; Machinski Jr, Miguel
- Abstract
The aim of this study was to evaluate the effects of thymol and carvacrol upon production of aflatoxins by Aspergillus flavus and upon its growth. Minimal inhibitory concentration (MIC), fungitoxic spectrum and mycotoxin inhibition were assessed. Results showed thymol and carvacrol exhibited fungicidal action, as determined by MIC values of 2500 and 30 μg mL-1, respectively. Both thymol and carvacrol significantly inhibited growth of A. flavus (p<0.05) at concentrations of 600 and 15 μg mL-1, respectively. Fungal biomass, as estimated by determination of ergosterol concentration, was significantly reduced (p<0.05) at thymol concentrations of 2500 μg mL-1 and at carvacrol concentrations of 250 μg mL-1. Thymol and carvacrol exhibited antiaflatoxigenic effects at concentrations of 600 and 125 μg mL-1, respectively. While both thymol and carvacrol showed possessing antifungal activities, neither were highly antiaflatoxigenic. Carvacrol and thymol might be considered for use as potential antifungal natural compounds against A. flavus.
- Subjects
ANTIFUNGAL agents; THYMOL; CARVACROL; ASPERGILLUS flavus; ERGOSTEROL
- Publication
Saúde e Pesquisa, 2021, Vol 14, Issue 1, p113
- ISSN
1983-1870
- Publication type
Article
- DOI
10.17765/2176-9206.2021v14n1.e7727