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- Title
Collapsing Glomerulopathy: A Single Centre Clinicopathologic Study of Seven Years.
- Authors
KANODIA, KAMAL V.; VANIKAR, ARUNA V.; PATEL, RASHMI D.; SUTHAR, KAMLESH S.; NIGAM, LOVELESH K.; PATEL, HIMANSHU V.; KUTE, VIVEK; TRIVEDI, HARGOVIND L.
- Abstract
Introduction: Collapsing Glomerulopathy (CG) is recognized as distinct pattern of proliferative parenchymal injury with poor response to empirical therapy. Aim: A single center retrospective study was carried out to find out clinicopathological features of idiopathic CG. Materials and Methods: A total of 3335 native renal biopsies were analyzed retrospectively which were performed from 2008 to 2014 with emphasis on clinicopathological correlation and histopathological presentation. Results: Idiopathic CG constituted 0.75% incidence (25 out of 3335 biopsies) of all biopsies, adults constituting major study part with 88%.The duration of the symptoms at the time of biopsy was 34.12±26.09 days and 35±22.91 days respectively in adults and children. Hypertension was noted in 9(40.9%) and oliguria in 8(36.4%) in adults. Urinalysis revealed microscopic haematuria 12(54.5%) in adults. Nephrotic range proteinuria was reported in 10 (45.5%) adult patients. Glomerular collapse with hyperplasia/ hypertrophy of podocytes was seen in 4.54±3.11 glomeruli. Tubular microcystic dilation was seen in 16(64%) patients. Tubular atrophy involving mild (t1) in 15(60%), moderate (t2) in 4(16%) and severe (t3) in 6(24%) patients. Interstitial fibrosis was mild (i1) in 17(68%), moderate (i2) in 2(8%) and severe (i3) in 6(24%) patients. Conclusion: Idiopathic CG is a morphological pattern of grave podocyte injury with poor prognosis. However, there are chances of remission/ recovery if the tubular atrophy and interstitial fibrosis are of grades ≤ t1 i1.
- Subjects
BLOOD circulation disorders; URINALYSIS; PROTEINURIA
- Publication
Journal of Clinical & Diagnostic Research, 2016, Vol 10, Issue 4, p15
- ISSN
0973-709X
- Publication type
Article
- DOI
10.7860/JCDR/2016/17297.7646