We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A Study of Serum Malondialdehyde and Cytokine in Tuberculosis Patients.
- Authors
KULKARNI, RASHMI; DESHPANDE, AJIT; SAXENA, RAVI; SAXENA, KIRAN
- Abstract
Introduction: Tuberculosis (TB) is a common and a deadly infectious disease which is caused by Mycobacterium tuberculi. Inflammatory cytokines play an important role during the course of the disease and they may be responsible for tissue damage which is caused by lipid peroxidation. Method: The present study was conducted in the Department of Biochemistry and patients were selected from Department of TB and Chest Sri Aurobindo Institute of Medical Sciences and also from Manorama Raje Tuberculosis Hospital, Indore. 32 healthy controls and 35 pulmonary TB patients were compared initially for their serum Malondialdehyde (MDA) and tumour necrosis factor alpha (TNF α) levels. Serum TNF α and MDA levels were correlated. Result: TNF α and MDA levels in serum were significantly increased (p<0.001) in pulmonary tuberculosis patients as compared to those of controls. Increased Serum TNF α was positively correlated to MDA levels and it was found to be statistically not significant (correlation coefficient r =0.282,p> 0.05 ). Conclusion: The present study supports the view that there may be a link between lipid peroxidation and cytokine response and relative roles of cytokines and lipid peroxidation in the pathogenesis of tuberculosis
- Subjects
TUBERCULOSIS; COMMUNICABLE diseases; MYCOBACTERIUM tuberculosis; CYTOKINES; PEROXIDATION
- Publication
Journal of Clinical & Diagnostic Research, 2013, Vol 7, Issue 10, p2140
- ISSN
0973-709X
- Publication type
Article
- DOI
10.7860/JCDR/2013/5736.3452