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- Title
Structure Elucidation and in Vitro Toxicity of New Azaspiracids Isolated from the Marine Dinoflagellate Azadinium poporum.
- Authors
Krock, Bernd; Tillmann, Urban; Potvin, Éric; Hae Jin Jeong; Wolfgang Drebing; Kilcoyne, Jane; Al-Jorani, Ahmed; Twiner, Michael J.; Göthel, Qun; Köck, Matthias
- Abstract
Two strains of Azadinium poporum, one from the Korean West coast and the other from the North Sea, were mass cultured for isolation of new azaspiracids. Approximately 0.9 mg of pure AZA-36 (1) and 1.3 mg of pure AZA-37 (2) were isolated from the Korean (870 L) and North Sea (120 L) strains, respectively. The structures were determined to be 3-hydroxy-8-methyl-39-demethyl-azaspiracid-1 (1) and 3-hydroxy-7,8-dihydro-39- demethyl-azaspiracid-1 (2) by 1H- and 13C-NMR. Using the Jurkat T lymphocyte cell toxicity assay, (1) and (2) were found to be 6- and 3-fold less toxic than AZA-1, respectively
- Subjects
IN vitro toxicity testing; DINOFLAGELLATES; HYDROXYMETHYL compounds; LYMPHOCYTES; CELL-mediated cytotoxicity
- Publication
Marine Drugs, 2015, Vol 13, Issue 11, p6687
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md13116687