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- Title
Polymorphism of the MICA gene and risk for oral submucous fibrosis.
- Authors
Liu, Chung‐Ji; Lee, Yann‐Jinn; Chang, Kuo‐Wei; Shih, Yi‐Ning; Liu, Hsin‐Fu; Dang, Ching‐Wen; Liu, Chung-Ji; Lee, Yann-Jinn; Chang, Kuo-Wei; Shih, Yi-Ning; Liu, Hsin-Fu; Dang, Ching-Wen
- Abstract
<bold>Background: </bold>Oral submucous fibrosis (OSF), an insidious, pre-cancerous, chronic disease that may affect the entire oral cavity and sometimes extend to the pharynx has been reported to be associated with immune function. The major histocompatibility complex (MHC) class I chain-related gene A (MICA) is expressed by keratinocytes and other epithelial cells, and its encoded protein interacts with gamma/delta T-cells localized in the submucosa. The MICA gene has a triplet repeat (GCT) polymorphism in the transmembrane domain resulting in five distinct allelic patterns.<bold>Methods: </bold>We analyzed MICA polymorphism in 80 OSF patients and 351 randomly selected unrelated controls by using the ABI Prism 377-18 DNA sequencer (Applied Biosystems) to analyze the sample DNA PCR products. The number of microsatellite repeats was estimated with Genescan 672 software (Applied Biosystems) with a standard size marker of GS-350 TAMRA.<bold>Results: </bold>The phenotype frequency of allele A6 of MICA in subjects with OSF was significantly higher than that in controls (OR = 3.48; 95% CI = 1.8-6.71; P = 0.0002), as was the frequency of the allele (OR = 2.65; 95% CI = 1.44-4.86; P = 0.001).<bold>Conclusion: </bold>The results suggest that allele A6 in MICA might confer a risk for OSF.
- Subjects
ORAL mucosa diseases; MAJOR histocompatibility complex; GENETIC polymorphisms; ALLELES; COMPARATIVE studies; CONFIDENCE intervals; DNA; GENES; HETEROCYCLIC compounds; HISTOCOMPATIBILITY antigens; RESEARCH methodology; MEDICAL cooperation; MEMBRANE proteins; ORAL diseases; PURINES; RESEARCH; SEX distribution; PHENOTYPES; EVALUATION research; SEQUENCE analysis; ODDS ratio
- Publication
Journal of Oral Pathology & Medicine, 2004, Vol 33, Issue 1, p1
- ISSN
0904-2512
- Publication type
journal article
- DOI
10.1111/j.1600-0714.2004.00047.x