We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Relationship of circulating CD4+ T-lymphocytes and p24 antigenemia to the risk of developing AIDS in HIV-infected subjects with oral hairy leukoplakia.
- Authors
Ravina, A.; Ficarra, G.; Chiodo, M.; Manetti, M.; Romagnani, S.; Mazzetti, M
- Abstract
To investigate the relationship of circulating CD4+ T-lymphocytes and p24 antigenemia to the development of AIDS in HIV-infected subjects with hairy leukoplakia (HL), we have followed over eight years 173 HIV-positive patients, all asymptomatic at the start of the study, and compared those who developed HL (n=55) to those who did not (n=118). Both groups included injection drug users (IDUs), homosexual men, and hemophiliacs. At the time of their first visit, both HL+ and HL- patients had a normal value of CD4+ cells and a low frequency of p24 antigenemia. During the years of follow-up, patients in the HL+ group showed a greater reduction in CD4+ cells, a significant increase in p24 antigenemia, and a higher rate of progression to AIDS. Our study demonstrates that in HIV-positive patients, HL is associated with more compromised immunological parameters and a higher viral replication and that its appearance has a negative prognostic value in relation to AIDS progression.
- Subjects
LYMPHOCYTES; AIDS; LEUKOPLAKIA; PATIENTS; HEMOPHILIACS; IMMUNOLOGY; INTRAVENOUS drug abuse; COMPARATIVE studies; HEMOPHILIA; HIV infections; HOMOSEXUALITY; ORAL leukoplakia; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; PROGNOSIS; PROTEINS; RESEARCH; T cells; EVALUATION research; HIV seroconversion; DISEASE progression; CD4 lymphocyte count
- Publication
Journal of Oral Pathology & Medicine, 1996, Vol 25, Issue 3, p108
- ISSN
0904-2512
- Publication type
journal article
- DOI
10.1111/j.1600-0714.1996.tb00203.x