We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A fluorescence in situ hybridization (FISH) analysis with centromere-specific DNA probes of chromosomes 3 and 17 in pleomorphic adenomas and adenoid cystic carcinomas.
- Authors
Xinwei Ll, Pieter J.; Tatsuo Tsuji, Pieter J.; Shumin Wen, Pieter J.; Yuka Mimura, Pieter J.; Zhaoyuan Wang, Pieter J.; Kohsuke Sasaki; Fumihiko Shinozaki, Pieter J.
- Abstract
Aberrations of chromosomes 3 and 17 were studied by FISH using centromerespecific DNA probes in 11 salivary adenoid cystic carcinomas (ACC) and 8 salivary pleomorphic adenomas (PA), with 3 lymph nodes as controls. Two hybridized signals were detected in 92.8±2.7% of controls, 73.2±7.0% of PA and 66.8±7.9% of ACC cells for chromosome 3, and in 90.4±2.3% of controls, 59.5±25.0% of PA and 44.8±20.2% of ACC for chromosome 17. More than 3 hybridized signals, which indicate polysomy, were observed in 3.1% of controls, 15.5% of PA and 22.9% of ACC cells for chromosome 3, and in 1.2% of controls, 10.3% of PA and 23.1% of ACC cells for chromosome 17. A single hybridized signal was much more frequent for chromosome 17 than for chromosome 3. These findings suggest that polysomy of both chromosomes occurs during the development of salivary gland tumors, and its frequency is increased in adenoid cystic carcinoma as compared to pleomorphic adenoma. In addition, monosomy of chromosome 17 could possibly be significant in salivary gland tumors.
- Subjects
CHROMOSOME abnormalities; ADENOID cystic carcinoma; DNA probes; NUCLEIC acid probes
- Publication
Journal of Oral Pathology & Medicine, 1995, Vol 24, Issue 9, p398
- ISSN
0904-2512
- Publication type
Article
- DOI
10.1111/j.1600-0714.1995.tb01208.x