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- Title
Analytical and diagnostic performance of Theradiag i-Tracker assays on IDS-iSYS for infliximab and adalimumab therapeutic drug monitoring.
- Authors
Herroelen, Pauline; Vanpoucke, Hilde; Baert, Filip; Decavele, An-Sofie; De Cuyper, Inge; Debrabandere, Johan; Martens, Geert A.; De Smet, Dieter
- Abstract
This letter discusses the analytical and diagnostic performance of Theradiag i-Tracker assays on IDS-iSYS for infliximab and adalimumab therapeutic drug monitoring. The study evaluated the linearity, imprecision, bias, and total error of the assays, as well as compared them to other commercially available enzyme-linked immunosorbent assays (ELISA). The results showed that the i-Tracker ADM assay performed well and could be a valuable alternative to the apDia ELISA. However, the i-Tracker IFX assay exhibited unacceptable bias compared to other IFX ELISAs and would require further optimization before clinical implementation. The study highlights the need for standardization and calibration adjustment of assays for TNF-α inhibitors.
- Subjects
DRUG monitoring; INFLIXIMAB; ADALIMUMAB; IMMUNOASSAY; CROHN'S disease
- Publication
Clinical Chemistry & Laboratory Medicine, 2024, Vol 62, Issue 8, pe181
- ISSN
1434-6621
- Publication type
Letter
- DOI
10.1515/cclm-2023-1432