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- Title
Comprehensive analysis of DTYMK in pan-cancer and verification in lung adenocarcinoma.
- Authors
Yue Zhang; HaoWang; Ying Liu; Jing Yang; Xiaoxiao Zuo; Meilian Dong; Zhigang Zhang; Yonggang Shi; Xubin Deng; Yaoyong Lv
- Abstract
Previous documents have reported that the deoxythymidylate kinase (DTYMK) genes were involved in the progression of cancers. However, its significance in the analysis of pan-cancer and specific molecular mechanism were still poorly understood. In the present study, we conducted a comprehensive study of the DTYMK gene associated with its clinical relevance across a broad-spectrum of human tumors. In addition, association among DTYMK gene and tumor immunogenic features was also explored. Considering the results of pan-cancer analysis, the specific tumor lung adenocarcinoma (LUAD) was chosen to further study the DTYMK-induced signaling pathways and intercellular communications in tumor progression. Our findings demonstrated that DTYMK may be a new biomarker for the prognosis and immunotherapy in various cancers. Importantly, DTYMK was expected to be a guiding marker gene for clinical prognosis and tumor personalized therapy in LUAD.
- Subjects
CELL communication; ADENOCARCINOMA; LUNG tumors; BIOMARKERS; LUNGS; TUMOR suppressor genes
- Publication
Bioscience Reports, 2022, Vol 42, Issue 10, p1
- ISSN
0144-8463
- Publication type
Article
- DOI
10.1042/BSR20221170