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- Title
Plantar fascia enthesopathy is highly prevalent in diabetic patients without peripheral neuropathy and correlates with retinopathy and impaired kidney function.
- Authors
Ursini, Francesco; Arturi, Franco; Nicolosi, Kassandra; Ammendolia, Antonio; D’Angelo, Salvatore; Russo, Emilio; Naty, Saverio; Bruno, Caterina; De Sarro, Giovambattista; Olivieri, Ignazio; Grembiale, Rosa Daniela
- Abstract
Background: Aim of this study was to evaluate the prevalence of plantar fascia (PF) enthesopathy in Type 2 diabetes mellitus (T2DM) patients without distal peripheral neuropathy (DPN). Methods: We recruited 50 T2DM patients without DPN and 50 healthy controls. DPN was excluded using the Michigan Neuropathy Screening Instrument (MNSI). All patients underwent a bilateral sonographicevaluation of the enthesealportion of the PF. Results: PF thickness was significantly higher in T2DM patients (p<0.0001). T2DM patients presented a higher prevalence of entheseal thickening (p = 0.002), enthesophyte (p = 0.02) and cortical irregularity (p = 0.02). The overall sum of abnormalities was higher in T2DM patients (p<0.0001), as was the percentage of bilateral involvement (p = 0.005). In a logistic regression analysis, retinopathy predicted entheseal thickening (OR 3.5, p = 0.05) and enthesophytes (OR 5.13, p = 0.001); reduced eGFR predicted enthesophytes (OR 2.93, p = 0.04); body mass index (BMI) predicted cortical irregularity (OR 0.87, p = 0.05); mean glucose predicted enthesophyte (OR 1.01, p = 0.03); LDL cholesterol predicted cortical irregularity (OR 0.98, p = 0.02). Conclusions: Our data suggest that T2DM is associated with PF enthesopathyindependently of DPN.
- Subjects
FASCIAE (Anatomy); TYPE 2 diabetes; KIDNEY function tests; CHOLESTEROL; ENTHESES
- Publication
PLoS ONE, 2017, Vol 12, Issue 3, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0174529