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- Title
Minimal variation of the plasma lipidome after delayed processing of neonatal cord blood.
- Authors
Wentworth, John M.; Bediaga, Naiara G.; Penno, Megan A. S.; Bandala-Sanchez, Esther; Kanojia, Komal N.; Kouremenos, Konstantinos A.; Couper, Jennifer J.; Harrison, Leonard C.; ENDIA Study Group
- Abstract
Background: Cord blood lipids are potential disease biomarkers. We aimed to determine if their concentrations were affected by delayed blood processing.Method: Refrigerated cord blood from six healthy newborns was centrifuged every 12 h for 4 days. Plasma lipids were analysed by liquid chromatography/mass spectroscopy.Results: Of 262 lipids identified, only eight varied significantly over time. These comprised three dihexosylceramides, two phosphatidylserines and two phosphatidylethanolamines whose relative concentrations increased and one sphingomyelin that decreased.Conclusion: Delay in separation of plasma from refrigerated cord blood has minimal effect overall on the plasma lipidome.
- Subjects
CORD blood; NEWBORN infant health; BIOLOGICAL tags; BLOOD testing; BLOOD plasma
- Publication
Metabolomics, 2018, Vol 14, Issue 10, p1
- ISSN
1573-3882
- Publication type
Article
- DOI
10.1007/s11306-018-1434-9