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- Title
Possible Modulation of Testosterone Secretion by Obestatin in Pubertal Male Rats.
- Authors
Jahan, Sarwat; Ahmed, Shakeel; Taqvim, Nazifa; Hizbullah
- Abstract
The article presents a study on the effect of different obestatin doses on the secretion of testosterone in pubertal male Sprague Dawley rats. The researchers isolated the 23-amino acid peptide encoded by the ghrelin gene from rat stomach, which is produced by the C terminal cleavage of preproghrelin. They also found obestatin in the rats' cerebral cortex, spleen and intestines using radioimmunoassay obestatin-specific antibodies. They concluded that the effects of obestatin on the concentrations of plasma testosterone in rodents are dependent on dose as well as on age.
- Subjects
TESTOSTERONE; SPRAGUE Dawley rats; AMINO acids; PEPTIDES; CEREBRAL cortex; IMMUNOGLOBULINS
- Publication
Pakistan Journal of Zoology, 2011, Vol 43, Issue 4, p799
- ISSN
0030-9923
- Publication type
Article