We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genetic Polymorphisms of X-ray Repair Cross-Complementing Group 1 and Apurinic/Apyrimidinic Endonuclease-1 in Chronic Obstructive Pulmonary Disease.
- Authors
Bardia, Avinash; Vishwakarma, Sandeep; Reddy, Chandrakala; Raju, N.; Iqbal, Shaik; Sravani, Gallapalli; Lavanya, Narneni; Begum, Nazima; Usma, Naziya; Nallari, Pratibha; Baderuzzaman; Ahmed, Syed; Hasan, Asfaq; Khan, Aleem
- Abstract
Chronic obstructive pulmonary disease (COPD) is a heterogeneous collection of conditions characterized by irreversible expiratory airflow limitation. The disease is interspersed with exacerbations; periods of acute symptomatic, physiological, and functional deterioration. The present study was designed to investigate the role of X-ray cross-complementing group 1 ( XRCC1) and apurinic/apyrimidinic endonuclease 1 ( APE1) polymorphisms and the risk of COPD. Blood samples from 354 unrelated subject (age range 18-60 years; 156 with COPD, 198 healthy controls) were collected. Genomic DNA was isolated and genotyped for XRCC1 Arg399Gln and APE1 Asp148Glu using a confronting two pair primers polymerase chain reaction. GA genotype of XRCC1 gene was found to be predominant in the COPD group compared to controls with 1.86-fold increased risk for COPD (OR 1.86, 95 % CI 1.20-2.88, p = 0.0013). TG genotype of APE1 was found to be predominant in COPD group compared to controls with the difference being statistically significant (OR 1.68, 95 % CI 1.08-2.61, p = 0.0043). The GA haplotype was found to be predominant in COPD than controls with a 2.19-fold significant increase (OR 2.19, 95 % CI 1.46-3.28, p = 0.003). Polymorphism in XRCC1 and APE1 gene is associated with an increased risk of COPD.
- Subjects
GENETIC polymorphisms; OBSTRUCTIVE lung disease treatment; ENDONUCLEASES; APURINIC acid; DISEASE exacerbation; POLYMERASE chain reaction
- Publication
Inflammation, 2016, Vol 39, Issue 3, p1198
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-016-0355-x