We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Heterodi- (Fe, Pd/Pt) and Heterotrimetallic (Fe<sub>2</sub>, Pd) Complexes Derived from 4-(Ferrocenylmethyl)- N-(2-methoxyethyl)-3,5-diphenylpyrazole as Potential Antitumoral Agents.
- Authors
Guillén, Eva; González, Asensio; López, Concepción; Basu, Pradipta K.; Ghosh, Amrita; Font‐Bardía, Mercè; Calvis, Carme; Messeguer, Ramón
- Abstract
The study of the reactivity of the pyrazole derivative 1-[MeO(CH2)2]-3,5-Ph2-4-(CH2Fc)-(C3N2) ( 1, Fc = ferrocenyl) with Na2[PdCl4], Pd(OAc)2, and [MCl2(dmso)2] (M = Pd or Pt, dmso = dimethyl sulfoxide) has allowed us to isolate trans-[Pd{κ- N-(1-{MeO(CH2)2}-3,5-Ph2-4-{CH2Fc}-{C3N2})}2Cl2] ( 2), [Pd{κ2- C, N(1-{MeO(CH2)2}-3-{C6H4}-5-Ph-{C3N2})}{κ- N-(1-{MeO(CH2)2}-3,5-Ph2-4-{CH2Fc}-{C3N2})}Cl] ( 3), [Pd{κ2- C, N(1-{MeO(CH2)2}-3-{C6H4}-4-{CH2Fc}-5-Ph-{C3N2})}Cl(PPh3)] ( 4), and the trans ( 5) and cis ( 6) isomers of [Pt{κ- N-(1-{MeO(CH2)2}-3,5-Ph2-4-{CH2Fc}-{C3N2})}Cl2(dmso)]. Compound 1 acts as a N (in 2, 5, and 6) or (C,N)- donor ligand (in 4) and shows both binding modes in 3. The cytotoxic assessment of 1- 6 against MCF7, MDA-MB231 (breast), and HCT-116 (colon) cancer cell lines reveal that (1) 1 is more potent than 1-[MeO(CH2)2]-3,5-Ph2-(C3HN2) ( V), (2) 2- 6 have cytotoxic activity, (3) 2 and 3 are less active than 4- 6, and (4) 6 is the most potent compound against the three cancer cell lines.
- Subjects
PYRAZOLES; HETEROCYCLIC compounds synthesis; SULFOXIDES synthesis; PROTEIN binding; PALLADIUM compounds; CANCER cells
- Publication
European Journal of Inorganic Chemistry, 2015, Vol 2015, Issue 22, p3781
- ISSN
1434-1948
- Publication type
Article
- DOI
10.1002/ejic.201500520