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- Title
Lack of Association between Tumour Necrosis Factor Receptor Superfamily Gene Polymorphisms and the Risk of Alzheimer's Disease in a Chinese Population.
- Authors
Ma, S. L.; Tang, Nelson L. S.; Lam, Linda C. W.; Tam, Cindy W. C.; Lui, Victor W. C.; Chiu, Helen F. K.
- Abstract
Objective: To investigate the association of polymorphisms in the tumour necrosis factor receptor 2 (TNFR2) and tumour necrosis factor superfamily, member 6 (TNFRSF6, FAS) genes and the risk of Alzheimer's disease (AD) in a Chinese population. Patients and Methods: One Hundred and fifty Chinese AD patients and 155 cognitively intact control subjects were recruited for the study. Genotypes of TNFR2+196, FAS-670, and FAS-1377 were investigated in this study by polymerase chain reaction-restriction fragment length polymorphisms. Results: The TNFR2+196 TT genotype was more prevalent in the AD group than in the controls. However, no significant difference in genotypic and allelic frequencies between AD and control groups (p = 0.68) was observed. Conclusion: We suggested that TNFR2+196, FAS-670, and FAS-1377 genotypes were not associated with the risk of AD in our Chinese population. However, evidence suggests involvement of tumour necrosis factor-alpha pathway in the pathogenesis of AD and a more comprehensive study may be required to identify the underlying associations.
- Subjects
CHINA; NECROSIS; GENETIC research; GANGRENE; GENETIC polymorphisms; ALZHEIMER'S disease risk factors; POLYMERASE chain reaction; TUMOR necrosis factors; HEALTH of Chinese people
- Publication
Hong Kong Journal of Psychiatry, 2006, Vol 16, Issue 4, p128
- ISSN
1026-2121
- Publication type
Article