We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A case of CD10-negative angioimmunoblastic T cell lymphoma with leukemic change and increased plasma cells mimicking plasma cell leukemia: A case report.
- Authors
YASUSHI ADACHI; TAKUYA HINO; MASAHIKO OHSAWA; KAZUHITO UEKI; TOMOKO MURAO; MING LI; YUNZE CUI; MITSUHIKO OKIGAKI; MITSUHIRO ITO; SUSUMU IKEHARA
- Abstract
Angioimmunoblastic T cell lymphoma (AITL) is a peripheral T cell lymphoma, known to express CD3 and CD4, and, frequently, also CD10 and c-Maf-1. Hypergammaglobulinemia is not particularly rare in patients with AITL. However, AITL in conjunction with plasmacytosis in the peripheral blood is rare. The current report presents a case of CD10-negative AITL demonstrating leukemic change and plasmacytosis in the peripheral blood mimicking plasma cell leukemia. A 78-year-old male was admitted to hospital due to systemic lymph node enlargement, high serum IgG and IgA, and increased counts of plasmacytoid cells and lymphoid cells with atypical nuclei in the peripheral blood. Initially, plasma cell leukemia was suspected, due to the extreme increase in the number of plasma cells in the peripheral blood. However, the plasma cells did not show clonal expansion on examination by flow cytometry. Based on histological analyses, following a biopsy of an enlarged lymph node, the patient was diagnosed with AITL. This case suggests that when hypergammaglobulinemia and increases in B-lineage cells are observed, AITL should be considered in addition to disorders of B-lineage cells.
- Subjects
T-cell lymphoma; HYPERGAMMAGLOBULINEMIA; PLASMA cell diseases; PLASMA cells; LEUKEMIA
- Publication
Oncology Letters, 2015, Vol 10, Issue 3, p1555
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2015.3490