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- Title
The inhibitory effects of various ions released from S-PRG fillers on dentin protease activity.
- Authors
SALIM, Ikram; SESEOGULLARI-DIRIHAN, Roda; Satoshi IMAZATO; TEZVERGIL-MUTLUAY, Arzu
- Abstract
This study investigates the effect of ions released from S-PRG fillers on host-derived enzymatic degradation of dentin collagen matrices. Dentin beams (n=80) were demineralized and distributed to eight groups following baseline dry mass and total MMP activity assessments. Each group treated with boron, fluoride, sodium, silicone, strontium, aluminium, or S-PRG eluate solutions for 5 min. Untreated beams served as control. After pre-treatment, MMP activity was reassessed, beams were incubated in complete medium for 1 week, dry mass was reassessed. Incubation media were analyzed for MMP and cathepsin-K-mediated degradation fragments. Data were analyzed with ANOVA and Tukey's test. All pretreatment groups showed significant reduction in total MMP activity (p<0.05) that was sustainable after incubation in all groups except for boron and silicone groups (p<0.05). Cathepsin-K activity did not differ between control or treatment groups. The results indicated that ions released from S-PRG fillers have the potential to partly inhibit MMP-mediated endogenous enzymatic activity.
- Subjects
DENTIN; TUKEY'S test; IONS
- Publication
Dental Materials Journal, 2023, Vol 42, Issue 1, p99
- ISSN
0287-4547
- Publication type
Article
- DOI
10.4012/dmj.2022-141