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- Title
Time-dependent responses in brain activity to ongoing hot stimulation in burning mouth syndrome.
- Authors
Ryutaro Kohashi; Takahiro Shinozaki; Naohiko Sekine; Kosuke Watanabe; Daiki Takanezawa; Chisa Nishihara; Kana Ozasa; Mariko Ikeda; Noboru Noma; Akiko Okada-Ogawa; Yoshiki Imamura; Kohashi, Ryutaro; Shinozaki, Takahiro; Sekine, Naohiko; Watanabe, Kosuke; Takanezawa, Daiki; Nishihara, Chisa; Ozasa, Kana; Ikeda, Mariko; Noma, Noboru
- Abstract
Burning mouth syndrome (BMS) is classified into idiopathic orofacial pain conditions. Although central and peripheral neuropathic mechanisms are believed to be involved, the etiology remains to be fully elucidated. The present study examined temporal brain responses to an ongoing hot stimulus to investigate the pain modulating system in patients with BMS. The thermal stimulation sequence comprised baseline (32°C, 40 s) to warm (40°C, 32 s) to baseline (32°C, 40 s) to hot (49°C, 32 s), which was repeated four times using a Peltier thermode. These warm and hot stimuli were applied on the right palm and right lower lip in two separate sessions. Functional magnetic resonance imaging data were acquired by recording echo-planar images with a block design. Brain activity induced by purely hot stimulation (49°C vs. 40°C) applied to the palm was more pronounced than that induced by lip stimulation and in patients with BMS compared with controls. Comparison of brain activity between the first 16 s and second 16 s of the stimulus revealed pronounced time-dependent facilitation in patients with BMS during lip stimulation. These findings indicate that the pain modulating system in patients with BMS is dysregulated and that the brain in BMS is highly sensitized to pain information originating from the trigeminal system.
- Subjects
BURNING mouth syndrome; LIPS; FUNCTIONAL magnetic resonance imaging; ECHO-planar imaging; OROFACIAL pain; BRAIN; PAIN measurement; MAGNETIC resonance imaging; LONGITUDINAL method
- Publication
Journal of Oral Science, 2020, Vol 62, Issue 2, p170
- ISSN
1343-4934
- Publication type
journal article
- DOI
10.2334/josnusd.18-0431