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- Title
In Vivo Activation of Mouse Macrophages with β-1,3-D-Glucan-Derivatized Plastic Beads.
- Authors
Seljelid, R.; Bøgwald, J.; Rasmussen, L.-T.; Larm, O.; Hoffman, J.; Berge, A.; Ugelstad, J.
- Abstract
Macrophages obtained from animals treated with β-1,3-D-glucan-derivatized plastic beads were greatly stimulated, as judged by morphology, esterase release, and cytostatic effect on L-929 tumour cells in vitro. The pretreatment of mice with such beads conferred an apparent absolute local resistance to an otherwise lethal pneumococcal infection but had no effect on the growth of intraperitoneal AA ascites sarcoma. Moreover, peritoneal cells from animals pretreated with glucan beads did not protect the animals in a Winn assay.
- Subjects
MACROPHAGES; RETICULO-endothelial system; CONNECTIVE tissue cells; ANTIGEN presenting cells; PHAGOCYTES; ESTERASES; HYDROLASES; CANCER cells; CELLULAR pathology
- Publication
Scandinavian Journal of Immunology, 1985, Vol 21, Issue 6, p601
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1985.tb01850.x