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- Title
Leukotriene C4 synthase A-444C gene polymorphism in patients with allergic rhinitis
- Authors
Eskandari, Hatice Gülçin; Ünal, Murat; Öztürk, Özlem Görüroğlu; Vayısoğlu, Yusuf; Muşlu, Necati
- Abstract
Objective: To determine the frequency of leukotriene C4 synthase A-444C polymorphism in allergic rhinitis patients. Study design and setting: A prospective, randomized, case-controlled study. Blood samples were obtained from 85 patients with allergic rhinitis and 95 healthy individuals. After the extraction of DNA from the blood samples, the leukotriene C4 synthase A-444C polymorphism was studied by a real-time polymerase chain reaction method. Results: The AC and CC genotype frequencies were statistically higher in the study group (P = 0.048 and P = 0.037, respectively). In addition, the AC polymorphism carried an increased risk of developing allergic rhinitis (odds ratio = 2.18, 95% confidence interval, 1.173-4.053, P = 0.014). Conclusion: The C allele of the leukotriene C4 synthase gene increases the risk of developing allergic rhinitis. Significance: The leukotriene C4 synthase A-444C gene polymorphism is important in susceptibility to allergic rhinitis and this is the first study of this gene polymorphism in allergic rhinitis. EBM rating: B-3b
- Subjects
GENETIC polymorphisms; ALLERGIC rhinitis; INFLAMMATION; POLYMERASE chain reaction
- Publication
Otolaryngology-Head & Neck Surgery, 2006, Vol 134, Issue 6, p997
- ISSN
0194-5998
- Publication type
Article
- DOI
10.1016/j.otohns.2006.02.007