We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A new allele of the testosterone-responsive gene, Hdc-a, in the histidine decarboxylase gene complex of the mouse.
- Authors
Middleton, Richard J.; Williamson, Kathleen; Bulfield, Grahame
- Abstract
In C57BL/10 and the majority of other strains of mice, females have about 20-fold higher kidney histidine decarboxylase levels than males; in DBA/2 mice, however, HDC in females is only 3- to 4-fold higher than males. The low ratio HDC phenotype of DBA/2 animals is due to decreased sensitivity of the HDC gene complex to repression by testosterone in males. From conventional crosses and by the use of the BXD recombinant inbred lines we conclude that the C57BL/ 10: DBA/2 difference, in testosterone sensitivity of HDC, is due to an allelic difference in the regulatory gene Hdc-a of the HDC gene complex, [Hdc], on chromosome 2; DBA/2 contains a third allele of this gene, Hdc-ad.
- Publication
Genetics Research, 1987, Vol 50, Issue 3, p213
- ISSN
0016-6723
- Publication type
Article
- DOI
10.1017/S0016672300023727