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- Title
Demyelination Causes Adult CNS Progenitors to Revert to an Immature State and Express Immune Cues That Support Their Migration.
- Authors
Moyon, Sarah; Dubessy, Anne Laure; Aigrot, Marie Stephane; Trotter, Matthew; Huang, Jeffrey K.; Dauphinot, Luce; Potier, Marie Claude; Kerninon, Christophe; Parsadaniantz, Stephane Melik; Franklin, Robin J. M.; Lubetzki, Catherine
- Abstract
The declining efficiency of myelin regeneration in individuals with multiple sclerosis has stimulated a search for ways by which it might be therapeutically enhanced. Here we have used gene expression profiling on purified murine oligodendrocyte progenitor cells (OPCs), the remyelinating cells of the adult CNS, to obtain a comprehensive picture of how they become activated after demyelination and how this enables them to contribute to remyelination. We find that adult OPCs have a transcriptome more similar to that ofoligodendrocytes than to neonatal OPCs, but revert to a neonatal-like transcriptome when activated. Part of the activation response involves increased expression of two genes of the innate immune system, IL1β and CCL2, which enhance the mobilization of OPCs. Our results add a new dimension to the role of the innate immune system in CNS regeneration, revealing how OPCs themselves contribute to the postinjury inflammatory milieu by producing cytokines that directly enhance their repopulation of areas of demyelination and hence their ability to contribute to remyelination.
- Subjects
DEMYELINATION; CENTRAL nervous system regeneration; PROGENITOR cells; IMMUNE system; CELL migration; GENE expression; CYTOKINES; LABORATORY mice
- Publication
Journal of Neuroscience, 2015, Vol 35, Issue 1, p4
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.0849-14.2015