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- Title
Management of autoimmune diseases after haematopoietic stem cell transplantation.
- Authors
Holbro, Andreas; Abinun, Mario; Daikeler, Thomas
- Abstract
Summary Autologous and allogeneic haematopoietic stem cell transplantation ( HSCT) is an option for the treatment of malignant and non-malignant diseases, including the severe autoimmune diseases. Intriguingly, the 'new' autoimmunity developing after transplantation is a constantly recognized phenomenon, which has to be differentiated from original disease relapse, toxicity, infection and graft- versus-host disease. The reported autoimmune diseases occurring in this setting are mainly antibody-associated and organ-specific, with scarce evidence in support for specific treatment options. This review focuses on current concepts on the pathogenesis, the available data on incidence, risk factors, manifestations and treatment of post- HSCT autoimmune diseases.
- Subjects
AUTOIMMUNE diseases; HEMATOPOIETIC stem cell transplantation; AUTOIMMUNITY; IMMUNOLOGIC diseases; AUTOANTIBODIES
- Publication
British Journal of Haematology, 2012, Vol 157, Issue 3, p281
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2012.09070.x