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Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology.
Published in:
Frontiers in Molecular Neuroscience, 2017, v. 10, p. 1, doi. 10.3389/fnmol.2017.00069
By:
- Maphis, Nicole M.;
- Shanya Jiang;
- Binder, Jessica;
- Wright, Carrie;
- Gopalan, Banu;
- Lamb, Bruce T.;
- Bhaskar, Kiran
Publication type:
Article
Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain.
Published in:
2015
By:
- Maphis, Nicole;
- Xu, Guixiang;
- Kokiko-Cochran, Olga N;
- Jiang, Shanya;
- Cardona, Astrid;
- Ransohoff, Richard M;
- Lamb, Bruce T;
- Bhaskar, Kiran
Publication type:
journal article
Loss of Inpp5d has disease‐relevant and sex‐specific effects on glial transcriptomes.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 8, p. 5311, doi. 10.1002/alz.13901
By:
- Dabin, Luke C.;
- Kersey, Holly;
- Kim, Byungwook;
- Acri, Dominic J.;
- Sharify, Daniel;
- Lee‐Gosselin, Audrey;
- Lasagna‐Reeves, Cristian A.;
- Oblak, Adrian L.;
- Lamb, Bruce T.;
- Kim, Jungsu
Publication type:
Article
The importance of continuing development of novel animal models of Alzheimer's disease and Alzheimer's disease and related dementias.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 7, p. 5078, doi. 10.1002/alz.14105
By:
- Wilcock, Donna M.;
- Lamb, Bruce T.
Publication type:
Article
Inpp5d haplodeficiency alleviates tau pathology in the PS19 mouse model of Tauopathy.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 7, p. 4985, doi. 10.1002/alz.14078
By:
- Soni, Disha M.;
- Lin, Peter Bor‐Chian;
- Lee‐Gosselin, Audrey;
- Lloyd, Christopher D.;
- Mason, Emily;
- Ingraham, Cynthia M.;
- Perkins, Abigail;
- Moutinho, Miguel;
- Lamb, Bruce T.;
- Chu, Shaoyou;
- Oblak, Adrian L.
Publication type:
Article
In vivo validation of late‐onset Alzheimer's disease genetic risk factors.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 7, p. 4970, doi. 10.1002/alz.13840
By:
- Sasner, Michael;
- Preuss, Christoph;
- Pandey, Ravi S.;
- Uyar, Asli;
- Garceau, Dylan;
- Kotredes, Kevin P.;
- Williams, Harriet;
- Oblak, Adrian L.;
- Lin, Peter Bor‐Chian;
- Perkins, Bridget;
- Soni, Disha;
- Ingraham, Cindy;
- Lee‐Gosselin, Audrey;
- Lamb, Bruce T.;
- Howell, Gareth R.;
- Carter, Gregory W.
Publication type:
Article
Characterizing molecular and synaptic signatures in mouse models of late‐onset Alzheimer's disease independent of amyloid and tau pathology.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 6, p. 4126, doi. 10.1002/alz.13828
By:
- Kotredes, Kevin P.;
- Pandey, Ravi S.;
- Persohn, Scott;
- Elderidge, Kierra;
- Burton, Charles P;
- Miner, Ethan W.;
- Haynes, Kathryn A.;
- Santos, Diogo Francisco S.;
- Williams, Sean‐Paul;
- Heaton, Nicholas;
- Ingraham, Cynthia M.;
- Lloyd, Christopher;
- Garceau, Dylan;
- O'Rourke, Rita;
- Herrick, Sarah;
- Rangel‐Barajas, Claudia;
- Maharjan, Surendra;
- Wang, Nian;
- Sasner, Michael;
- Lamb, Bruce T.
Publication type:
Article
Transgenic amyloid precursor protein mouse models of amyloidosis. Incomplete models for Alzheimer's disease but effective predictors of anti‐amyloid therapies.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 2, p. 1459, doi. 10.1002/alz.13566
By:
- Morgan, David G.;
- Lamb, Bruce T.
Publication type:
Article
A target enablement package for modulating the activity of PLCγ2 as a therapeutic strategy for the treatment of Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.074712
By:
- Clayton, Brent;
- Bissel, Stephanie J;
- Richardson, Timothy I;
- Massey, Steven M;
- Beck, Daniel E;
- Putt, Karson S;
- Bedford, Logan M;
- Utsuki, Tada;
- Visvanathan, Ramya;
- Mesecar, Andrew D;
- Lendy, Emma K;
- Kaiser, Bridget L;
- Chu, Shaoyou;
- Mason, Emily R;
- Quinney, Sara K;
- Kandasamy, Murugesh;
- Masters, Andrea R;
- Lamb, Bruce T;
- Palkowitz, Alan D;
- Sondek, John
Publication type:
Article
Assessing the Role of PLCG2*M28L Risk In A Novel Mouse Model Late‐Onset Alzheimer's Disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079180
By:
- Territo, Paul R;
- Oblak, Adrian L;
- Persohn, Scott C;
- Bedwell, Amanda A;
- Eldridge, Kierra;
- Kotredes, Kevin P;
- Pandey, Ravi S;
- Rizzo, Stacey J Sukoff;
- Carter, Gregory W;
- Sasner, Michael;
- Howell, Gareth R;
- Lamb, Bruce T
Publication type:
Article
MR1/MAIT cell axis in the temporal development of Alzheimer's disease pathology.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078273
By:
- Johnson, Season Kealyn;
- Kersey, Holly N;
- Codocedo, Juan F;
- Newell, Kathy L;
- Landreth, Gary E;
- Lamb, Bruce T;
- Oblak, Adrian L;
- Brutkiewicz, Randy R
Publication type:
Article
Novel mouse models of late‐onset Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078958
By:
- Sasner, Michael;
- Oblak, Adrian L;
- Pandey, Ravi S;
- Uyar, Asli;
- Garceau, Dylan;
- Kotredes, Kevin P;
- Soni, Disha;
- Lin, Peter Bor‐Chian;
- Ingraham, Cynthia;
- Lamb, Bruce T;
- Howell, Gareth R;
- Carter, Gregory W
Publication type:
Article
Elucidating the complex role of ABCA7 in late‐onset Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078038
By:
- Howell, Gareth R;
- Kotredes, Kevin P;
- Pandey, Ravi S;
- Rizzo, Stacey J Sukoff;
- Carter, Gregory W;
- Sasner, Michael;
- Lamb, Bruce T;
- Oblak, Adrian L;
- Territo, Paul R
Publication type:
Article
An Integrative Multi‐Omics Approach Reveals Molecular Signatures Associated with Age and High‐Fat Diet in Mouse Models of Alzheimer's Disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077260
By:
- Pandey, Ravi S;
- Kotredes, Kevin P;
- Garceau, Dylan;
- Haber, Annat;
- MahmoudianDehkordi, Siamak;
- Shantaraman, Anantharaman;
- Duong, Duc M.;
- Seyfried, Nicholas T;
- Kaddurah‐Daouk, Rima F.;
- Sasner, Michael;
- Howell, Gareth R;
- Oblak, Adrian L;
- Lamb, Bruce T;
- Carter, Gregory W
Publication type:
Article
Leveraging MODEL‐AD mouse strains to understand the role of toxicant exposures on LOAD risk.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.072777
By:
- Howell, Gareth R;
- Kotredes, Kevin P;
- Minaeva, Olga;
- Moncaster, Juliet A;
- Haber, Annat;
- Pandey, Ravi S;
- Rizzo, Stacey J Sukoff;
- Territo, Paul R;
- Lamb, Bruce T;
- Sasner, Michael;
- Oblak, Adrian L;
- Carter, Gregory W;
- Goldstein, Lee E
Publication type:
Article
Novel mouse models of late‐onset Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078958
By:
- Sasner, Michael;
- Oblak, Adrian L;
- Pandey, Ravi S;
- Uyar, Asli;
- Garceau, Dylan;
- Kotredes, Kevin P;
- Soni, Disha;
- Lin, Peter Bor‐Chian;
- Ingraham, Cynthia;
- Lamb, Bruce T;
- Howell, Gareth R;
- Carter, Gregory W
Publication type:
Article
Elucidating the complex role of ABCA7 in late‐onset Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078038
By:
- Howell, Gareth R;
- Kotredes, Kevin P;
- Pandey, Ravi S;
- Rizzo, Stacey J Sukoff;
- Carter, Gregory W;
- Sasner, Michael;
- Lamb, Bruce T;
- Oblak, Adrian L;
- Territo, Paul R
Publication type:
Article
An Integrative Multi‐Omics Approach Reveals Molecular Signatures Associated with Age and High‐Fat Diet in Mouse Models of Alzheimer's Disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077260
By:
- Pandey, Ravi S;
- Kotredes, Kevin P;
- Garceau, Dylan;
- Haber, Annat;
- MahmoudianDehkordi, Siamak;
- Shantaraman, Anantharaman;
- Duong, Duc M.;
- Seyfried, Nicholas T;
- Kaddurah‐Daouk, Rima F.;
- Sasner, Michael;
- Howell, Gareth R;
- Oblak, Adrian L;
- Lamb, Bruce T;
- Carter, Gregory W
Publication type:
Article
Leveraging MODEL‐AD mouse strains to understand the role of toxicant exposures on LOAD risk.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.072777
By:
- Howell, Gareth R;
- Kotredes, Kevin P;
- Minaeva, Olga;
- Moncaster, Juliet A;
- Haber, Annat;
- Pandey, Ravi S;
- Rizzo, Stacey J Sukoff;
- Territo, Paul R;
- Lamb, Bruce T;
- Sasner, Michael;
- Oblak, Adrian L;
- Carter, Gregory W;
- Goldstein, Lee E
Publication type:
Article
Application of neurovascular uncoupling and whole brain network connectomics to assess the role of genetic and dietary risk factors in the LOAD2 mouse model.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.065967
By:
- Silvola, Rebecca;
- Persohn, Scott C;
- Oblak, Adrian L;
- Lamb, Bruce T;
- Bedwell, Amanda A;
- Eldridge, Kierra;
- Speedy, Rachael;
- Howell, Gareth R;
- Sasner, Michael;
- Territo, Paul R
Publication type:
Article
The niacin receptor HCAR2 induces a protective response of microglia to amyloid pathology.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.065160
By:
- Moutinho, Miguel;
- Puntambekar, Shweta S;
- Tsai, Andy Po‐Yi;
- Coronel, Isarel;
- Lin, Peter Bor‐Chian;
- Casali, Brad T;
- Martínez, Pablo;
- Oblak, Adrian L;
- Reeves, Cristian A Lasagna;
- Lamb, Bruce T;
- Landreth, Gary E
Publication type:
Article
A novel, humanized late‐onset Alzheimer's disease mouse model expressing APOEe4, Trem2<sup>*</sup>R47H, and amyloid‐beta.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.064485
By:
- Kotredes, Kevin P;
- Oblak, Adrian L;
- Pandey, Ravi S;
- Territo, Paul R;
- Rizzo, Stacey J Sukoff;
- Carter, Gregory W;
- Sasner, Michael;
- Howell, Gareth R;
- Lamb, Bruce T
Publication type:
Article
INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 6, p. 2528, doi. 10.1002/alz.12849
By:
- Lin, Peter Bor‐Chian;
- Tsai, Andy Po‐Yi;
- Soni, Disha;
- Lee‐Gosselin, Audrey;
- Moutinho, Miguel;
- Puntambekar, Shweta S.;
- Landreth, Gary E.;
- Lamb, Bruce T.;
- Oblak, Adrian L.
Publication type:
Article
A clinically relevant mouse model of the Trem2*R47H Alzheimer's disease risk variant.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.067173
By:
- Sasner, Michael;
- Oblak, Adrian L;
- Garceau, Dylan;
- Kotredes, Kevin P;
- Preuss, Christoph;
- Uyar, Asli;
- Pandey, Ravi S;
- Lin, Peter Bor‐Chian;
- Tsai, Andy Po‐Yi;
- Carter, Gregory W;
- Howell, Gareth R;
- Lamb, Bruce T
Publication type:
Article
Impact of Phospholipase C Gamma 2 Alzheimer's Disease Variants on Microglial Biology and Disease Pathogenesis.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.066966
By:
- Tsai, Andy Po‐Yi;
- Lin, Peter Bor‐Chian;
- Dong, Chuanpeng;
- Prisco, Gonzalo Viana Di;
- Wang, Nian;
- Bissel, Stephanie J;
- Oblak, Adrian L;
- Moutinho, Miguel;
- Liu, Yunlong;
- Atwood, Brady;
- Nho, Kwangsik;
- Lamb, Bruce T;
- Landreth, Gary E
Publication type:
Article
The role of Abca7 in late‐onset Alzheimer's disease animal models.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.067665
By:
- Oblak, Adrian L;
- Kotredes, Kevin P;
- Ingraham, Cynthia;
- Territo, Paul R;
- Rizzo, Stacey J Sukoff;
- Carter, Gregory W;
- Sasner, Michael;
- Howell, Gareth R;
- Lamb, Bruce T
Publication type:
Article
Cx3cr1 deficiency aggravates Aβ driven neurodegeneration and cognitive decline in a mouse model of Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.066024
By:
- Puntambekar, Shweta S;
- Moutinho, Miguel;
- Lin, Peter Bor‐Chian;
- Jadhav, Vaishnavi;
- Tumbleson‐Brink, Danika;
- Balaji, Ananya;
- Benito, Martin A;
- Xu, Guixiang;
- Oblak, Adrian L;
- Reeves, Cristian A Lasagna;
- Landreth, Gary E;
- Lamb, Bruce T
Publication type:
Article
INPP5D inhibition attenuates amyloid pathology through the regulation of microglial functions.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.063702
By:
- Lin, Peter Bor‐Chian;
- Tsai, Andy Po‐Yi;
- Soni, Disha;
- Lee‐Goseelin, Audrey;
- Nho, Kwangsik;
- Lamb, Bruce T;
- Oblak, Adrian L
Publication type:
Article
Cerebral perfusion and glucose metabolism profiling reveal special phenotypes in the hAPOE3, hAPOE4, Trem2 risk, and doubled risks mice.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.063682
By:
- Lin, Peter Bor‐Chian;
- Persohn, Scott C;
- Bedwell, Amanda A;
- Jiang, Lei;
- Eldridge, Kierra;
- Speedy, Rachael;
- Kotredes, Kevin P;
- Pandey, Ravi S;
- Williams, Harriet M;
- Oblak, Adrian L;
- Sasner, Michael;
- Howell, Gareth R;
- Carter, Gregory W;
- Lamb, Bruce T;
- Territo, Paul R
Publication type:
Article
Differential vulnerability of hippocampal microstructure in 5xFAD mouse model of Alzheimer's Disease: A dMRI study.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, p. 1, doi. 10.1002/alz.066288
By:
- Shahid, Syed Salman;
- Lamb, Bruce T;
- Oblak, Adrian L;
- Wu, Yu‐Chien
Publication type:
Article
The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 10, p. 1765, doi. 10.1002/alz.12577
By:
- Claes, Christel;
- England, Whitney E.;
- Danhash, Emma P.;
- Kiani Shabestari, Sepideh;
- Jairaman, Amit;
- Chadarevian, Jean Paul;
- Hasselmann, Jonathan;
- Tsai, Andy P.;
- Coburn, Morgan A.;
- Sanchez, Jessica;
- Lim, Tau En;
- Hidalgo, Jorge L. S.;
- Tu, Christina;
- Cahalan, Michael D.;
- Lamb, Bruce T.;
- Landreth, Gary E.;
- Spitale, Robert C.;
- Blurton‐Jones, Mathew;
- Davtyan, Hayk
Publication type:
Article
LOAD2: A late‐onset Alzheimer's disease mouse model expressing APOEε4, Trem2*R47H, and humanized amyloid‐beta.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.056017
By:
- Kotredes, Kevin P;
- Oblak, Adrian L;
- Preuss, Christoph;
- Pandey, Ravi S;
- Territo, Paul R;
- Rizzo, Stacey J Sukoff;
- Carter, Gregory W;
- Sasner, Michael;
- Howell, Gareth R;
- Lamb, Bruce T.
Publication type:
Article
Evaluation of late‐onset Alzheimer's disease risk variants in mouse models.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.055629
By:
- Sasner, Michael;
- Oblak, Adrian L;
- Garceau, Dylan;
- Kotredes, Kevin P;
- Soni, Disha;
- Lin, Peter Bor‐Chian;
- Preuss, Christoph;
- Uyar, Asli;
- Pandey, Ravi S;
- Carter, Gregory W;
- Lamb, Bruce T.;
- Howell, Gareth R
Publication type:
Article
The synergistic role of high‐fat diet and genetic predisposition in Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.055514
By:
- Oblak, Adrian L;
- Kotredes, Kevin P;
- Reagan, Alaina M;
- Pandey, Ravi S;
- Sasner, Michael;
- Carter, Gregory W;
- Lamb, Bruce T.;
- Howell, Gareth R
Publication type:
Article
PLCG2 expression is associated with plaque‐associated microglia in Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.054755
By:
- Tsai, Andy Po‐Yi;
- Dong, Chuanpeng;
- Moutinho, Miguel;
- Lin, Peter Bor‐Chian;
- Casali, Brad T;
- Bissel, Stephanie J;
- Oblak, Adrian L;
- Liu, Yunlong;
- Landreth, Gary E;
- Lamb, Bruce T.;
- Nho, Kwangsik
Publication type:
Article
INPP5D as a potential therapeutic target against Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.053236
By:
- Lin, Peter Bor‐Chian;
- Tsai, Andy Po‐Yi;
- Nho, Kwangsik;
- Lamb, Bruce T.;
- Oblak, Adrian L
Publication type:
Article
Creating, characterizing, and validating the next generation of mouse models for late‐onset Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.049954
By:
- Carter, Gregory W;
- Howell, Gareth R;
- Lamb, Bruce T.;
- Oblak, Adrian L;
- Rizzo, Stacey J Sukoff;
- Sasner, Michael;
- Territo, Paul R
Publication type:
Article
Impact of PLCG2 expression on Microglial Biology and Disease Pathogenesis in Alzheimer's Disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.058740
By:
- Tsai, Andy Po‐Yi;
- Lin, Peter Bor‐Chian;
- Dong, Chuanpeng;
- Moutinho, Miguel;
- Liu, Yunlong;
- Bissel, Stephanie J;
- Oblak, Adrian L;
- Nho, Kwangsik;
- Lamb, Bruce T.;
- Landreth, Gary E
Publication type:
Article
INPP5D regulates the amyloid pathology in Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.058724
By:
- Lin, Peter Bor‐Chian;
- Tsai, Andy Po‐Yi;
- Nho, Kwangsik;
- Lamb, Bruce T.;
- Oblak, Adrian L
Publication type:
Article
N‐of‐1‐pathways transcriptomic analysis reveals distinct subtypes of Alzheimer's disease: Development of new models and analysis methods/novel assays and technologies.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.046575
By:
- Uyar, Asli;
- Pandey, Ravi S.;
- Preuss, Christoph;
- Kotredes, Kevin P.;
- Oblak, Adrian L.;
- Logsdon, Benjamin A.;
- Rizzo, Stacey J. Sukoff;
- Howell, Gareth;
- Lamb, Bruce T.;
- Sasner, Michael;
- Carter, Gregory W.
Publication type:
Article
Deep phenotyping of the 5XFAD model: IU/JAX/PITT MODEL‐AD center: Development of new models and analysis methods/novel assays and technologies.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.045981
By:
- Oblak, Adrian L.;
- Carter, Gregory W.;
- Howell, Gareth;
- Rizzo, Stacey J. Sukoff;
- Sasner, Michael;
- Territo, Paul R.;
- Ash, Carl T.;
- Ingraham, Cynthia;
- Kotredes, Kevin P.;
- Bleckert, Adam;
- Masek, Marissa;
- Patel, Neil;
- Chidambaram, Ritesh;
- Ragan, Tim;
- Lamb, Bruce T.
Publication type:
Article
Transcriptomic profiling of APOE4/Trem2*R47H mouse models for late‐onset Alzheimer's disease: Development of new models and analysis methods/novel assays and technologies.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.045390
By:
- Pandey, Ravi S.;
- Kotredes, Kevin P.;
- Preuss, Christoph;
- Oblak, Adrian L.;
- Lamb, Bruce T.;
- Howell, Gareth;
- Sasner, Michael;
- Carter, Gregory W.
Publication type:
Article
Hallmarks of late‐onset Alzheimer's disease in a humanized mouse model: Development of new models and analysis methods/screening studies/platforms.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.045162
By:
- Kotredes, Kevin P.;
- Preuss, Christoph;
- Pandey, Ravi S.;
- Territo, Paul R.;
- Oblak, Adrian L.;
- Kaddurah‐Daouk, Rima F.;
- Arnold, Matthias;
- Seyfried, Nicholas T.;
- Duong, Duc;
- Williams, Harriet M.;
- Lamb, Bruce T.;
- Rizzo, Stacey J. Sukoff;
- Carter, Gregory W.;
- Sasner, Michael;
- Howell, Gareth
Publication type:
Article
Identification and characterization of immune‐focused therapeutic targets in the MODEL‐AD and TREAT‐AD consortia: Microbiome in Alzheimer's disease: Pathogenesis and treatment implications.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.044157
By:
- Lamb, Bruce T.;
- Palkowitz, Alan David;
- Howell, Gareth;
- Carter, Gregory W.;
- Territo, Paul R.;
- Oblak, Adrian L.;
- Rizzo, Stacey J. Sukoff;
- Sasner, Michael
Publication type:
Article
In vivo testing of the role of Alzheimer's disease coding variants: Functionalizing genetic variants in Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.043896
By:
- Sasner, Michael;
- Oblak, Adrian L.;
- Garceau, Dylan;
- Kotredes, Kevin P.;
- Preuss, Christoph;
- Pandey, Ravi S.;
- Uyar, Asli;
- Lamb, Bruce T.;
- Carter, Gregory W.;
- Howell, Gareth
Publication type:
Article
Neurovascular uncoupling of cerebral blood flow and glucose metabolism in APOE4, TREM2, and APOE4.TREM2 mice: Development of new models and analysis methods/novel assays and technologies.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.041531
By:
- Territo, Paul R.;
- Lin, Peter B.;
- Persohn, Scott C.;
- Bedwell, Amanda A.;
- Eldridge, Kierra;
- Speedy, Rachael;
- Kotredes, Kevin P.;
- Pandey, Ravi S.;
- Oblak, Adrian L.;
- Sasner, Michael;
- Carter, Gregory W.;
- Lamb, Bruce T.;
- Howell, Gareth
Publication type:
Article
Pharmacokinetic, pharmacodynamic and transcriptomic analyses of verubecestat treatment in 5XFAD mice: Development of new models and analysis methods/novel assays and technologies.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.041491
By:
- Territo, Paul R.;
- Quinney, Sara K.;
- Biesdorf, Carla;
- Masters, Andrea R.;
- Onos, Kristen;
- Haynes, Leslie;
- Keezer, Kelly;
- Cope, Zackery A.;
- Meyer, Jill A.;
- Peters, Jonathan;
- Persohn, Scott C.;
- Figueiredo, Lucas;
- Bedwell, Amanda A.;
- Eldridge, Kierra;
- Speedy, Rachael;
- Sasner, Michael;
- Howell, Gareth;
- Carter, Gregory W.;
- Oblak, Adrian L.;
- Lamb, Bruce T.
Publication type:
Article
The IUSM‐Purdue Alzheimer's Disease Drug Discovery Center: A member of the NIH‐funded TREAT‐AD consortium: Nonhuman/Novel screening strategies.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.041107
By:
- Palkowitz, Alan David;
- Lamb, Bruce T.;
- Oblak, Adrian L.;
- Reeves, Cristian A. Lasagna;
- Territo, Paul R.;
- Rizzo, Stacey J. Sukoff
Publication type:
Article
Scientific Advising and Reviewing: On strengthening the bond between the Alzheimer's Association and the scientific community.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 7, p. 1095, doi. 10.1002/alz.12059
By:
- Knopman, David;
- Lemere, Cynthia A.;
- Lamb, Bruce T.;
- Craft, Suzanne;
- Gitlin, Laura N.;
- Golde, Todd E.;
- Pericak‐Vance, Margaret;
- Sano, Mary;
- Schellenberg, Gerard;
- Schneider, Julie A.;
- Zheng, Hui;
- Khachaturian, Zaven;
- Snyder, Heather M.;
- Carrillo, Maria C.
Publication type:
Article
P4‐098: TRANSCRIPTOMIC ALTERATIONS DRIVEN BY THE TREM2*R47H ALLELE VARY ACROSS DIFFERENT TRANSGENIC MOUSE MODELS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1312, doi. 10.1016/j.jalz.2019.06.3758
By:
- Uyar, Asli;
- Oblak, Adrian L.;
- Williams, Harriet M.;
- Pandey, Ravi S.;
- Kotredes, Kevin P.;
- Preuss, Christoph;
- Logsdon, Benjamin A.;
- Sukoff Rizzo, Stacey J.;
- Howell, Gareth;
- Lamb, Bruce T.;
- Sasner, Michael;
- Carter, Gregory W.
Publication type:
Article

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