We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Protective Effect of Piperine and Its Derivatives on SH-SY5Y Cells.
- Authors
MU Li-hua; LIU Ping; HU Yuan; LIAO Hong-bo; LI Jia-jia
- Abstract
The piperine was modified and four derivatives was synthesised. SH-SY5Y cell was lesion by High concertation cort to stimulate the neuro cell in depression or anxiety. Five compounds were screened for protective activity on SH-SY5Y. Piperine, 5-(3,4-methylenedioxy phenyl)-2E, 4E-pentadienoic acid n-propylamine amide (2) and 5-(3,4-methylenedioxy phenyl)-2E, 4E-pentadienoic acid N-methyl piperazine amide (4)showed protective activities on SH-SY5Y cells. Compound 2 showed notable protective effect on SH-SY5Y cells from the lesion done by cort.
- Subjects
CELLS; ORGANIC compounds; ANXIETY; MENTAL depression; AMIDES
- Publication
Natural Product Research & Development, 2010, Vol 22, Issue 3, p408
- ISSN
1001-6880
- Publication type
Article