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- Title
Myeloperoxidase-Antineutrophil Cytoplasmic Antibody–Positive Otitis Media and Rhinosinusitis With Pathological Features of Immunoglobulin G4-Related Disease.
- Authors
Ohno, Keiko; Matsuda, Yoko; Arai, Tomio; Sugihara, Takahiko; Iga, Shoko; Kimura, Yurika
- Abstract
Background: Immunoglobulin G4-related disease (IgG4-RD) and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) have different clinical and pathological features. However, differentiation between these 2 disorders is sometimes difficult. Objective: To report a case involving a patient with characteristics of both IgG4-RD and AAV. Methods: Case report with literature review. Results: We report a case of myeloperoxidase-ANCA–positive otitis media and rhinosinusitis with pathological features of IgG4-RD in a 73-year-old man. The patient was first clinically suspected to have granulomatosis with polyangiitis. All of the main characteristic pathological features of IgG4-RD were present: dense lymphoplasmacytic infiltration, increased numbers of IgG4-positive plasma cells, storiform-type fibrosis, and obliterative phlebitis. Conclusions: The simultaneous presence of the characteristics of both IgG4-RD and AAV makes diagnosis and treatment difficult.
- Subjects
COMPUTED tomography; IMMUNOGLOBULINS; OTITIS media; SINUSITIS; VASCULITIS
- Publication
Annals of Otology, Rhinology & Laryngology, 2016, Vol 125, Issue 6, p516
- ISSN
0003-4894
- Publication type
Article
- DOI
10.1177/0003489415625072