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- Title
Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model.
- Authors
Yun Wang; Lei Jing; Xiao-Min Zhao; Ji-Ju Han; Zuo-Li Xia; Shu-Cun Qin; Ya-Ping Wu; Xue-Jun Sun
- Abstract
Background: Hydrogen-rich saline has been reported to have antioxidant and anti-inflammatory effects and effectively protect against organ damage. Oxidative stress and inflammation contribute to the pathogenesis and/or development of pulmonary hypertension. In this study, we investigated the effects of hydrogen-rich saline on the prevention of pulmonary hypertension induced by monocrotaline in a rat model. Methods: In male Sprague-Dawley rats, pulmonary hypertension was induced by subcutaneous administration of monocrotaline at a concentration of 6 mg/100 g body weight. Hydrogen-rich saline (5 ml/kg) or saline was administred intraperitoneally once daily for 2 or 3 weeks. Severity of pulmonary hypertension was assessed by hemodynamic index and histologic analysis. Malondialdehyde and 8-hydroxy-desoxyguanosine level, and superoxide dismutase activity were measured in the lung tissue and serum. Levels of pro-inflammatory cytokines (tumor necrosis factor-a, interleukin-6) in serum were determined with enzyme-linked immunosorbent assay. Results: Hydrogen-rich saline treatment improved hemodynamics and reversed right ventricular hypertrophy. It also decreased malondialdehyde and 8-hydroxy-desoxyguanosine levels, and increased superoxide dismutase activity in the lung tissue and serum, accompanied by a decrease in pro-inflammatory cytokines. Conclusions: These results suggest that hydrogen-rich saline ameliorates the progression of pulmonary hypertension induced by monocrotaline in rats, which may be associated with its antioxidant and antiinflammatory effects.
- Subjects
PULMONARY hypertension treatment; PULMONARY hypertension prevention; PHYSIOLOGIC salines; MONOCROTALINE; DISEASE progression; LABORATORY rats; THERAPEUTICS
- Publication
Respiratory Research, 2011, Vol 12, Issue 3, p1
- ISSN
1465-9921
- Publication type
Article
- DOI
10.1186/1465-9921-12-26