We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Alcohol Intake and Cigarette Smoking and Risk of a Contralateral Breast Cancer: The Womens Environmental Cancer and Radiation Epidemiology Study.
- Authors
Julia A. Knight; Leslie Bernstein; Joan Largent; Marinela Capanu; Colin B. Begg; Lene Mellemkjær; Charles F. Lynch; Kathleen E. Malone; Anne S. Reiner; Xiaolin Liang; Robert W. Haile; John D. Boice; WECARE Study Collaborative Group; Jonine L. Bernstein
- Abstract
Women with primary breast cancer are at increased risk of developing second primary breast cancer. Few studies have evaluated risk factors for the development of asynchronous contralateral breast cancer in women with breast cancer. In the Womens Environmental Cancer and Radiation Epidemiology Study (1985â2001), the roles of alcohol and smoking were examined in 708 women with asynchronous contralateral breast cancer (cases) compared with 1,399 women with unilateral breast cancer (controls). Cases and controls aged less than 55 years at first breast cancer diagnosis were identified from 5 population-based cancer registries in the United States and Denmark. Controls were matched to cases on birth year, diagnosis year, registry region, and race and countermatched on radiation treatment. Risk factor information was collected by telephone interview. Rate ratios and 95% confidence intervals were estimated by using conditional logistic regression. Ever regular drinking was associated with an increased risk of asynchronous contralateral breast cancer (rate ratioâ=â1.3, 95% confidence interval: 1.0, 1.6), and the risk increased with increasing duration (Pâ=â0.03). Smoking was not related to asynchronous contralateral breast cancer. In this, the largest study of asynchronous contralateral breast cancer to date, alcohol is a risk factor for the disease, as it is for a first primary breast cancer.
- Subjects
UNITED States; DENMARK; BREAST cancer risk factors; PHYSIOLOGICAL effects of tobacco; PHYSIOLOGICAL effects of alcohol; ENVIRONMENTALLY induced cancer; EPIDEMIOLOGY of cancer; CANCER radiotherapy; CANCER in women; EPIDEMIOLOGICAL research
- Publication
American Journal of Epidemiology, 2009, Vol 169, Issue 8, p962
- ISSN
0002-9262
- Publication type
Article